From in-Vitro Data to Virtual Patients: Development of an in-Silico Model of Acne Pathogenesis for Prioritizing Targets for Novel Acne Therapies and Prediction of Late Stage Clinical Outcomes Conference PresentationAIChE Annual MeetingNovember 10, 2015Quantitative Systems Pharmacology (QSP) is an integrated systems-level modeling approach that combines the fields of pharmacology and systems biology...
Proteomic Time Profiling of Mab Producing CHO Fed-Batch Bioreactor Cultures Conference PresentationAIChE Annual MeetingNovember 10, 2015The production of recombinant proteins such as monoclonal antibodies (mAbs) is usually based on complex mammalian cell processes. Rising omics...
Tools for Engineering Non-Growth Metabolism Conference PresentationAIChE Annual MeetingNovember 9, 2015Stationary phase metabolism that is not carbon-limited is ideal for metabolic engineering. Without cell growth, feedstocks can be efficiently...
Sponsored Webinar: Chemical Reactivity Management Archived Webinar May 10, 2017 Could there be potential reactive hazards in your facility you’re not aware of? Don’t let undesired reactions lead to uncontrolled situations and reactive chemical incidents. In this ioKinetic sponsored webinar, learn an approach to identifying and characterizing reactive materials and how to...
Purifying Water in Developing Countries Archived Webinar Sep 21, 2016 Engineers know how to produce safe drinking water, but transferring it to those in need is another story. In this webinar, Dr. Velegol discusses her experience developing a technology using the seeds of the Moringa oleifera tree to clean water. Hear her scientific results and lessons learned while...
Sponsored Webinar: Mixer Simulations, Modeling Non-Ideal Reactors and Mixers Archived Webinar Jun 25, 2015 Mathematical modeling and simulations of reactors and mixers can be done at different levels of detail for different purposes. The initial use of a model may be to run simulations in order to understand the process at hand. A fairly detailed model is then required in order to account for the main...
Intro to Maintenance and Reliability Archived Webinar Mar 11, 2015 This presentation provides those in the process and discrete manufacturing industries an introduction to the best practices in Maintenance and Reliability aimed at improving uptime and productivity. The relationship between asset care delivery and equipment performance are highlighted. Work...
Accellerase® Trio: Advances in Cellulosic Enzymes for Commercial Biorefineries Conference PresentationAIChE Annual MeetingNovember 1, 2012Providing nearly 400 enzyme products ranging from food and beverages to household cleaning and biofuels, Genencor has been a world leader in...
On the Modeling of Oral Drug Delivery Conference PresentationAIChE Annual MeetingNovember 1, 2012On the Modeling of Oral Drug Delivery Naresh Pavurala, Luke E.K Achenie Department of Chemical Engineering, Virginia Polytechnic Institute and State...
Piloting Bioreactors for Agitation Scale-Up February2008Reactions and SeparationsGregory T. BenzThis article offers guidance on how to design appropriate experiments to measure scalable data for agitation in both aerobic and anaerobic bioreactors.
A Personal Perspective on Biotechnology's Progress in a Golden Era (and how Jay Bailey saw it all coming) Conference PresentationAIChE Annual MeetingNovember 18, 2014Much has changed in biotechnology over the last few decades, but much has remained the same. As a graduate student in Jay Bailey’s research group in...
The Effect of Types of Lignocellulosic Biomass on Autohydrolysis Liquor Inhibitor Composition Conference PresentationAIChE Annual MeetingNovember 18, 2014A liquor stream from autohydrolysis pretreatment of lignocellulosic biomass is enriched in dissolved hemicellulose and lignin-derived compounds,...
Single Use Centrifuge- CHO Clarification Conference PresentationAIChE Annual MeetingNovember 7, 2013Abstract Text: The large scale economic collection of proteins is an important problem for the Biotechnology industry. Generally , proteins are...
Fischer-Tropsch Synthesis: Comparison of Process Based On Fossil and Biomass Feedstock Conference PresentationAIChE Annual MeetingNovember 7, 2013The conversion of synthesis gas to fuels is independent of the feedstock once the proper ratio of hydrogen/carbon monoxide has been obtained. In one...
Biomasspyrolysisrefinery: Product Stability of Intermediates and Products Conference PresentationAIChE Annual MeetingNovember 6, 2013The BiomassPyrolysisRefinery is a dual step concept for biomass liquefaction and hydrogenation, intending production of liquid energy carriers. First...
Effect of Anti-Apoptosis Genes On Clarification Performance Conference PresentationAIChE Annual MeetingNovember 6, 2013Optimal bioreactor harvest time is typically determined based on maximizing product titer without compromising product quality. We suggest that ease...
Cooling Water Issues Follow up Solutions to Microbiologically Induced Corrosion Conference PresentationAIChE Spring Meeting and Global Congress on Process SafetyApril 30, 2013In the 2007 turnaround at the BASF TOTAL PETROCHEMICALS LLC Ethylene Steam Cracker, severe damage was discovered in the cooling tower water to...
Enhancement in Enzymatic Hydrolysis by Mechanical Refining of Pretreated Biomass Conference PresentationAIChE Annual MeetingNovember 1, 2012Cellulose is the most abundant natural polymer. Therefore, cellulosic bioethanol has been identified as a fuel source that has tremendous potential...
Generating Complex Biological Traits through Combinatorial and Multigenome Expansion of the Sampling Space Conference PresentationAIChE Annual MeetingOctober 30, 2012There are many complex phenotypes/strains that are desirable for practical applications in the context of Cell or Metabolic Engineering . One example...
A Century of Chemical Engineering Thermodynamics Education: Biological Applications in Thermodynamics Education Conference PresentationAIChE Annual MeetingNovember 17, 2008The field of chemical engineering has evolved into areas of biochemical engineering, nanotechnolgy, product design, and other emerging fields...
Bioreactor Design for Chemical Engineers August2011Back To BasicsGregory T. BenzFermentation processes are based on chemical engineering principles. Understand these concepts to achieve optimal bioreactor design.
Catalyzing Commercialization: Zero-CO2-Emission Fermentation Technology Facilitates Efficient Routes to Biobased Chemicals January2016Catalyzing CommercializationThe production of bioethanol fuel by fermentation generates a significant amount of CO 2 as a byproduct; every ton of ethanol produced is accompanied by a ton of CO 2 , which not only impacts the environment but also process yields and therefore...
Fermentation Goes Large-Scale January2003Special SectionAristos Aristidou , J. J. Hahn , Pim van Hoek , Alex PatistDesigning an economically competitive and environmentally sustainable fermentation route means considering the downstream separations needed to capture the final product during the initial process design.
Clarifying Centrifuge Operation and Selection August2004Fluids and Solids HandlingVictor Norton , William WilkieBefore selecting a centrifuge for your application, understand its principles of operation and investigate the key process variables.
Keys to Bioreactor Selection March2002Reactions and SeparationsJohn A. WilliamsA few basic types of bioreactor designs are used to produce a wide range of products, from antibiotics to foods to fuels. Here's how to pick the best options for your application.
Compact Heat Exchangers, Part 2: Using Plate Exchangers in Heat Recovery Networks October2002Heat TransferChristopher Haslego, Graham T. Polley Here's how to incorporate plate-and-frame exchangers into new plant design using pinch analysis.