Biomedical Engineering

SBE Special Section: Translational Medicine (Complete 44-Page Section)

May
2018
SBE Special Section
Engineering the Precise Translation of Novel Medicines; From Data to Diagnosis: The Search for Biochemical Markers of Autism Spectrum Disorder; Designing Drug Delivery Systems for Articular Joints; Curtailing Antiobiotic Use in Livestock Production; Recent Advances in Hydrogels for Tissue Engineering; Going Small is Big: Creating Organoids for Regenerative Medicine; Direct Production of Engineered Cardiac Tissue within Hybrid Biomaterials

May 2018 CEP Preview

May 18, 2018

This month, brush up on the essentials of continuous evaporation, learn new uses for hydrofoil impellers, enjoy the special section on translational medicine, and more.

Designing Drug Delivery Systems for Articular Joints

May
2018
SBE Special Section
Brett C. Geiger, Alan J. Grodzinsky, Paula Hammond
No disease-modifying drug exists for osteoarthritis due to poor drug delivery within joints. Engineered biomaterials could address this challenge by improving the duration and targeting of therapies.

Direct Production of Engineered Cardiac Tissue within Hybrid Biomaterials

May
2018
SBE Special Section
Morgan Ellis, Elizabeth Lipke
The human heart contains highly specialized cells that are especially vulnerable to damage because they lack regenerative capabilities. This article describes a novel method for encapsulating and directly differentiating induced pluripotent stem cells in hybrid biomaterials to form cardiac tissue.

Engineering the Precise Translation of Novel Medicines

May
2018
SBE Special Section
The field of bioengineering has placed engineers at the frontier of human health. In fact, medical schools at Univ. of Illinois Urbana-Champaign, Texas A&M, and other universities are developing programs with an “engineering-centric medicine” approach.

Going Small Is Big: Creating Organoids for Regenerative Medicine

May
2018
SBE Special Section
Ogechi Ogoke, Mitchell H. Maloy, Saber Meamardoost, Natesh Parashurama
Organoids are a promising tool to replicate key structural and functional features of human organs. Recent developments in organoids to model the liver, biliary tract, and pancreas have the potential to advance regenerative medicine.

Recent Advances in Hydrogels for Tissue Engineering

May
2018
SBE Special Section
Samad Ahadian, Houman Savoji, Ali Khademhosseini
Hydrogels could play an important role in the fabrication of functional tissues for regenerative medicine. This article describes the developments in polymer chemistry, nanomaterials, molecular biology, and microscale technologies that are spurring advances in hydrogel fabrication.

Curtailing Antibiotic Use in Livestock Production

May
2018
SBE Special Section
Yiannis N. Kaznessis
For decades, livestock producers have routinely administered antibiotics to animals to make them grow faster or as a preventive treatment against disease. This may be contributing to the increasing number of humans being infected by antibiotic-resistant bacteria. Researchers are now searching for viable alternatives.

Books: April 2018

April
2018
Books
The Future of Humanity: Terraforming Mars, Interstellar Travel, Immortality, and Our Destiny Beyond Earth Michio Kaku, Doubleday, New York, NY, $29.95, 368 pages, Feb. 2018, ISBN: 978-0-385-54276-0 Moving human civilization beyond Earth’s bounds is...

Your Experiences Leave a Mark

February 13, 2018
Epigenetics — the study of how our actions and experiences mark or modify our DNA — can explain some unusual genetic findings.

Chemical Engineers as Biomedical Innovators

Archived Webinar
Aug 7, 2013
The design of biomedical materials is rooted in principles of chemical engineering. This presentation describes the connections between chemical engineering and biomedical innovations, and discusses the translation of novel materials into clinical applications.

Microengineered Hydrogels for Stem Cell Bioengineering and Tissue Regeneration

Archived Webinar
Aug 23, 2011
Micro- and nanoscale technologies are emerging as powerful tools for controlling the interaction between cells and their surroundings for biological studies, tissue engineering, and cell-based screening. In addition, hydrogel biomaterials have been increasingly used in various tissue engineering...

Engineering and Health Care

Archived Webinar
May 16, 2011
Dr. Langer discusses the involvement of engineering in health care, from the discovery of the first angiogenesis inhibitors to the development of controlled drug delivery systems and the foundation of tissue engineering.

Multi-Scale Agent-Based Modeling of Human Endotoxemia

Conference Presentation
AIChE Annual Meeting
November 8, 2010
The systemic inflammatory response syndrome (SIRS) often accompanies critical illness but is evoked by many stimuli e.g. infection, trauma, invasive...

A System Approach to Astrocytoma Progression

Conference Presentation
AIChE Annual Meeting
November 8, 2010
Astrocytomas are brain cancers that account for 75% of neuroepithelial tumors. Accurate diagnosis is required for adequate treatment and assessing...

Body-on-a-Chip -- A Tool for Predictive Pharmacology/Toxicology

Archived Webinar
Mar 31, 2009
In this presentation, Professor Mike Shuler details his work to understand the response of the human body to various pharmaceutical and environmental chemicals using a combination of whole body modules and micro models Professor Shuler’s research focuses on microfabricated devices combined with...

Systems Biology: Open Challenges and Opportunities for Chemical Engineers

Archived Webinar
Jan 20, 2009
Systems biology involves the analysis of multiple scales of 'control' in biological networks, from the regulation of gene transcription to the homeostatic regulation of metabolism in the whole body. These natural control circuits are paragons of optimality: over millennia, they have been honed to...

November 2017 CEP Preview

November 13, 2017

Chemical engineers' response to the addiction epidemic, cogeneration operation basics, an overview of Colombia's chemical industry, and more.

Computational Protein Engineering

October
2017
SBE Special Section
Robert Pantazes
Proteins could transform the chemical process industries if they could be engineered to facilitate the production of biofuels, molecular medicines, and other specialty chemicals. This reality is nearing as expanded knowledge of proteins and improvements in computational tools are making it possible to design specific protein structures and functions.

Engineering Cancer-Fighting T Cells

October
2017
SBE Special Section
Eugenia Zah, Yvonne Y. Chen
Adoptive T-cell therapy is a personalized cancer treatment that has the potential to cure previously untreatable malignancies. Researchers are applying techniques in biomolecular engineering and synthetic biology to the development of next-generation therapeutic T cells with improved safety and efficacy against a variety of cancers.

There’s Plenty of Room at the Bottom of a Cell

October
2017
SBE Special Section
Angela R. Wu, Lei Yu
Single-cell RNA sequencing is giving engineers and scientists the ability to better understand and manipulate the smallest unit of a living organism — the single cell. This technique has already ushered in breakthroughs in biology and medicine. However, challenges and opportunities abound.

SBE Special Section: Biomolecular Engineering (full 34-page section)

October
2017
SBE Special Section
SBE Update: The Many Applications of Biomolecular Engineering; A Materials Approach to Vaccines as Therapies; Engineering Cancer-Fighting T Cells; There's Plenty of Room at the Botton of a Cell; Computational Protein Engineering; Plant Metabolic Engineering for Chemicals, Fuels, and Precursors

Profile: Developing Novel Solutions to Improve Patient Care

June
2017
Profile
Lonnie Shea, a professor and chair in the Dept. of Biomedical Engineering at the Univ. of Michigan, is an internationally recognized researcher whose work spans the fields of regenerative medicine, biomaterials, and gene and drug delivery. His research seeks to advance technologies and solutions at the interface of engineering and medicine.

Little Bio-Machinery to Solve Grand Challenges

January 3, 2017
As we approach ICBE 2017, which begins this weekend in San Diego, we look back at some of the exciting research that figured among 2016's highlights and look forward to the new developments to be unveiled at ICBE 2017.
Magnified view of the Drosophila melanogaster fruit fly

Fruit Fly Finding Could Fight Human Cancers

January 26, 2017

Researchers at Indiana University Bloomington have discovered that a molecule related to some forms of cancer and neurodegenerative disorders is also present in developing Drosophila melanogast

Study Points to Therapeutic Cancer Vaccine

December 30, 2016

Researchers at the University of Michigan have had a significant breakthrough in creating a customized therapeutic vaccine for treating colon and melanoma cancer tumors in mice.

SBE’s 6th International Conference on Bioengineering and Nanotechnology

February 21, 2012

This year's meeting, Bionanoscience and Bioengineering for Translational Medicine, will foster greater knowledge exchange and collaboration in the areas of bioengineering and nanotechnology – two interdisciplinary fields that cut across and integrate various areas in science, engineering, and medicine to create breakthroughs in biomedical research.

Immune Cells Engineered to Resist HIV

January 23, 2013

Researchers at Stanford have devised a new way of engineering key cells of the immune system to resist HIV, according to a report issued yesterday by the university.

Pharma Turns to Gut for New Drugs

January 25, 2016

The past few years have been full of stories about how a number of serious conditions could be treated or cured by introducing certain bacteria to the digestive system.

Printing A Human Kidney

December 27, 2011

Atala, whose team developed the first lab-grown organ, explains how his lab's 3-D printing technology is used to create human organs. In addition to the bladder that was transplanted, Wake Forest has also managed to engineer miniature kidneys from bio-materials and cells.

Human Platelets Generated in Vitro

July 23, 2014

Researchers have successfully created a bioreactor that generates human platelets in vitro, potentially addressing blood transfusion needs worldwide.

Polymer Nanotubes that Resemble Nerve Structures

August 26, 2015

Researchers at Sandia National Laboratories have created linkages of polymer nanotubes that resemble the structure of a nerve and are capable of transmitting electrical impulses.

Technology Can Stop the Zika Virus, but Should It?

February 9, 2016
If you could eradicate the Aedes aegypti mosquito responsible for spreading the Zika virus in the Americas, would you? And should you? Those are some of the big questions being tossed about among biologists, ecologists, public health experts, and others today because the technology exists to bid farewell to the pesky mosquito.

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