Browse Issue Articles in this Issue A novel mammalian cell line development platform utilizing nanofluidics and optoelectro positioning technology Achieving greater efficiency and higher confidence in single - cell cloning by combining cell printing and plate imaging technologies An examination of critical parameters in hybridization - based epigenotyping using magnetic microparticles Assessing Escherichia coli metabolism models and simulation approaches in phenotype predictions: Validation against experimental data Biogas purification via optimal microalgae growth: A literature review Cell culture media for recombinant protein expression in Chinese hamster ovary (CHO) cells: History, key components, and optimization strategies Comparison of time - gated surface - enhanced raman spectroscopy (TG - SERS) and classical SERS based monitoring of Escherichia coli cultivation samples Data - driven multi - objective optimization via grid compatible simplex technique and desirability approach for challenging high throughput chromatography applications Enhancement of transgene expression by nuclear transcription factor Y and CCCTC - binding factor Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivity and the sulfhydryl - drug conjugation process Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy High - throughput screening of antibody - expressing CHO clones using an automated shaken deep - well system Identifying new clotting factor XIa inhibitors in virtual high - throughput screens using PCA - GA - SVM models and signature Immobilization of tobacco etch virus (TEV) protease on a high surface area protein nanofibril scaffold Issue Information Lipase - catalyzed hydrolysis of (R,S) - 2,3 - diphenylpropionic methyl ester enhanced by hydroxypropyl - β - cyclodextrin Prediction of recombinant protein production by Escherichia coli derived online from indicators of metabolic burden Quantitative assessment of environmental impact of biologics manufacturing using process mass intensity analysis Rapid creation system of morphologically and functionally communicative three - dimensional cell - dense tissue by centrifugation Review and in silico analysis of fermentation, bioenergy, fiber, and biopolymer genes of biotechnological interest in Agave L. for genetic improvement and biocatalysis Saponins and microbial biosurfactants: Potential raw materials for the formulation of cosmetics Separation of α - ketoglutaric acid and pyruvic acid from the culture broth of Yarrowia lipolytica WSH - Z06 by chromatographic methods Shift to high - intensity, low - volume perfusion cell culture enabling a continuous, integrated bioprocess SpheroidSim-Preliminary evaluation of a new computational tool to predict the influence of cell cycle time and phase fraction on spheroid growth The effect of feed quality due to clarification strategy on the design and performance of protein A periodic counter - current chromatography This issue has a lot going on & moving on Tissue and organ decellularization in regenerative medicine Volatile fatty acids production from protease pretreated Chlorella biomass via anaerobic digestion Cover Date: November/December 2018