Engineered Yeast Churn Out Synthetic PLGA | AIChE

Engineered Yeast Churn Out Synthetic PLGA


Engineers have given yeast the ability to produce a biodegradable, biocompatible, nontoxic synthetic polymer that is used in biomedical applications, such as surgical sutures, prosthetic devices, drug delivery, and tissue engineering.

Poly(lactate-co-glycolate) (PLGA) — a copolymer of lactic and glycolic acids — is typically synthesized by random ring-opening copolymerization of lactide and glycolide in the presence of catalysts, including tin(II) 2-ethylhexanoate and aluminum isopropoxide. The process is complicated and involves several steps, including the purification of precursors, polymerization, and the removal of unreacted raw materials and unused catalyst. The removal steps also add costs to the process.

To address these issues, researchers at the Korea Advanced Institute of Science and Technology (KAIST) engineered Escherichia coli to produce PLGA in a one-step fermentation process directly from carbohydrates. They were able to modify the microorganism’s genetics to enable it to selectively produce a diverse range of different PLGAs...

Would you like to access the complete CEP News Update?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. AIChE Membership

    You must be an AIChE member to view this article. Join now.

Copyright Permissions 

Would you like to reuse content from CEP Magazine? It’s easy to request permission to reuse content. Simply click here to connect instantly to licensing services, where you can choose from a list of options regarding how you would like to reuse the desired content and complete the transaction.