The gCrystal software suite’s easy-to-use, drag-and-drop graphical environment permits model-based innovation, engineering, and optimization of solution-crystallization processes, including precipitation. The program enables the creation of detailed models containing first-principles representations of the complex physics and chemistry of crystallization. The results can be used to develop high-fidelity predictive models, which can help to optimize crystallization process design and operation, determine optimal process economics, and manage risks associated with engineering decisions for both batch and continuous processes. These new model-based techniques enhance scaleup efforts to improve throughput and size consistency, often accompanied by energy savings. The program is suitable for use in pharmaceutical, food, chemicals, and mineral processing applications.