Microfluidics has long been promised as a solution to complex molecular assays with real biomedical relevance. The delivery on this promise has been strenuous at best. Molecular biology assays often require multi-step process that is hard to conduct in a fixed tiny volume offered by microfluidics. In this talk, I will discuss strategies that we developed in recent years to enable low-input genome-wide assays on microfluidic platforms. I will also describe how we use these assays to generate insights into brain neuroscience processes.
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