Crystallization in Process Chemistry: Applying Simple PAT Tools

Crystallization is a unit operation offering a method to isolate and purify products in a single step. At the same time, crystallization is a complex process where it is possible to have multiple process variables interacting to affect the properties of the size, shape, yield, form and purity of the crystal product.

Many published studies have shown the value of process analytical technologies (PAT) for drastic improvement in the ability to characterize, optimize, and scale-up, and control robust crystallization processes. However, many process analytical techniques, such as FBRM and ATR-FTIR spectroscopy, provide complex data that sometimes limits their adoption to crystallization experts and specialized engineering groups.

Real-time microscopy with simple image analysis has been developed to provide a direct measurement of the relative backscatter index (RBI), offering an opportunity for every scientist to utilize Process Analytical Technology PAT in the design, analysis, optimization, and control of crystallization processes.