Break
AIChE Annual Meeting
2018
2018 AIChE Annual Meeting
Separations Division
Hybrid Separation Processes
Sunday, October 28, 2018 - 4:36pm to 4:58pm
ABSTRACT:
Hydrogels that swell in response to pH changes in the human body are excellent carriers for the controlled release of drugs. We present an experimental and modeling study of drug encapsulation and release from pH-responsive hydrogel spheres. Drug encapsulated hydrogel spheres are synthesized by dropwise addition of blend of chitosan solution and aspirin solution in different proportions into the concentrated sodium hydroxide solution. The synthesized hydrogel spheres are characterized using FESEM. Drug encapsulation and release studies are performed at different pH, representative of physiological conditions in the human body. The experimental results are complemented with a mathematical model for drug release from pH-responsive hydrogel spheres.
Hydrogels that swell in response to pH changes in the human body are excellent carriers for the controlled release of drugs. We present an experimental and modeling study of drug encapsulation and release from pH-responsive hydrogel spheres. Drug encapsulated hydrogel spheres are synthesized by dropwise addition of blend of chitosan solution and aspirin solution in different proportions into the concentrated sodium hydroxide solution. The synthesized hydrogel spheres are characterized using FESEM. Drug encapsulation and release studies are performed at different pH, representative of physiological conditions in the human body. The experimental results are complemented with a mathematical model for drug release from pH-responsive hydrogel spheres.