(748a) A Novel Method to Measure Powder Flow Properties Using a Small Amount of Material

Authors: 
Koynov, S., Rutgers University
Scicolone, J. V., Rutgers University
Glasser, B. J., Rutgers University
Muzzio, F. J., Rutgers University

One of the most frequently used bulk property characterization methods is the measurement of the change in bulk density as a function of applied normal stress; also known as compressibility.  Historically, this was measured at two conditions: loose packing (i.e. bulk density ) and maximum packing (i.e. tapped density).  More recently, the compressibility technique as performed using the Freeman Technology FT4 measures the change in bulk density as several points over a range of applied normal stress (0.5 – 15kPa).  The result of this technique is a profile, as opposed to two points, and is more reproducible due to the conditioning step in the procedure.  However, this test requires a large powder sample on the order of tens of grams.

Many applications have limited sample availability, such as pharmaceutical drug development.  Therefore, a method that uses less material is of interest.  Further, the determination of the minimum amount of material required to achieve the same results is of interest.  This work introduces a novel compressibility method that uses less than 50mg of material.  This method is validated against the FT4 compressibility test.