(350a) Light-Curable Bioactive Polymeric Composite Glues for Bone Defect Treatment

Authors: 


Recent
research on bone implant materials targets combination of resorption and
sufficient mechanical properties [1]. Photopolymerizable
degradable resins are particularly attractive to clinicians as they allow
accurate control on initiation of the hardening process. However a major
drawback is the difficulty to set them in vivo. We will demonstrate the
introduction of a reactive filler into a light-curable, clinically used polymer
and its effect on adhesion to wet bone surfaces in a close to in vivo
setup (see figure) [2].

In
this present study, we combine an advanced light-curable clinical polymer mixture
consisting of bisphenol A diglycidyl
methacrylate and tri(ethylene glycol) dimethacrylate (BisGMA/TEGDMA) with most recently developed reactive amorphous calcium
phosphate (a-CaP) nanoparticles [3] as filler.
Here we will present an investigation of in vitro biomineralization, compressive
strength and preliminary tests on adhesion to bone. The hypothesis within this
study is that the performance of the adhesive polymer can be increased through
the incorporation of the inorganic filler. The incorporation of 20 wt.% amorphous calcium phosphate (a-CaP) nanoparticles in
the adhesive polymer significantly improved the adhesion to wet bone.

This
work gives access to light-curable polymers with significantly improved bone
adhesion.  New frontiers and possibilities in complex bone defects treatment
using light-curing polymeric biomaterials to be discussed.

 Fig 6

Figure 1: Adhesion to bone: (a) Schematic
test setup. (b) Image of a glued polycarbonate rod on a fresh cut cow
hip bone after light-curing of the sample. (c) Pull-out test in a conventional
testing machine.

References: [1] J.L. Ifkovits, J.A.
Burdick, Tiss. Eng., 2007, 13(10),
2369.

[2] O. D. Schneider, A. Stepuk,
D. Mohn, N. A. Luechinger, K. Feldman, W. J. Stark,  Act. Biomat. 2010,
6, 2704.

[3] T.J. Brunner, M. Bohner, C. Dora, C. Gerber, W.J.
Stark, J. Biomed. Mater. Res. Part B, 2007, 83, 400.