Advances in Cell Culture

As the number and quantity of recombinant proteins in development and commercial production has increased over the last few years, the demand on process development and manufacturing facilities has increased as well. While some of this demand can be met by building new infrastructures and facilities, a more efficient and less costly means of meeting these needs is by designing higher productivity processes that are well characterized and robust. This session will focus on recent developments in the field of cell culture process development and engineering with emphasis on enhancing yield and improving robustness of the culture process (i.e., excluding cell line manipulations). Topics include, but are not limited to, advances in bioprocess optimization, bioreactor design and operation, control schemes, scale up/scale down methods, and process analytical techniques for cell culture.