(395a) Think out of the Box - a Case Study of a Photosensitivity Phenomenon during Mab Product Recovery | AIChE

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(395a) Think out of the Box - a Case Study of a Photosensitivity Phenomenon during Mab Product Recovery

Authors 

Zhao, X. - Presenter, Amgen


Primary Recovery is a key step to link cell culture and purification. In monoclonal antibody production, a typical recovery process includes centrifugation, filtration and capture chromatography. Most recovery optimization is focused on improving the process yield and reducing its cost.

A case study is presented here of a photosensitivity phenomenon with potential impact to product stability. The main contributing factors that caused the photosensitivity were identified and process conditions developed to minimize these effects.

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