Nate Hathaway, Ph.D. is an Assistant Professor in the Division of Chemical Biology and Medicinal Chemistry in the UNC Eshelman School of Pharmacy. He is also a member of the Center for Integrative Chemical Biology and Drug Discovery and the Lineberger Comprehensive Cancer Center. His lab studies how chromatin is dynamically regulated in the cell, allowing for varying levels of gene expression or gene silencing. Dr. Hathaway’s research is focused on the discovery of new small molecules that inhibit epigenetic pathways both for research purposes and as potential future therapeutics.
My lab studies how chromatin is dynamically regulated in the cell, allowing for varying levels of gene expression or gene silencing. Our approach to understanding chromatin biology involves the use of chemical tools to manipulate cellular events, which allows us to examine the direct activity of individual enzymes on complex substrates such as chromatin. We have created a unique tool called the Chromatin in vivo Assay (CiA) mouse, which enables us to selectively control chromatin with defined activities in living cells. Using this technology, we can examine the requirements for creating an “epigenetic state”, a stable regulatory mechanism capable of transmitting information through cellular generations.
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