Dr. Karen Reddy is an assistant professor of biological chemistry at the Johns Hopkins University School of Medicine. Her research focuses on understanding how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation.
The focus of the research in the Reddy lab is to begin to understand how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation. Understanding the cell biology of genomes and how nuclear architecture controls gene expression is necessary to truly understand biological processes such as development and disease.
Although sequencing of the genome and comparative genome analysis have yielded insights into the regulation and dis-regulation of genetic information, these efforts shed little light on how genomes actually work in vivo. The impact of the architectural and cellular organization of genomes on gene activity is a next step to unlocking genetic and epigenetic mechanisms in development and disease. Specifically, they are trying to understand how genes are regulated at the nuclear periphery, decipher how genes are localized (or “addressed”) to specific nuclear compartments and, finally, determine how these processes are utilized in the development and corrupted in disease.
for more information please visit https://www.hopkinsmedicine.org/research/labs/karen-reddy-laboratory