Jeff Barrick | AIChE

Jeff Barrick

Associate Professor
The University of Texas at Austin

We use experiments with microorganisms, nucleic acids, and digital organisms to study evolution in action with the ultimate goal of understanding and harnessing evolution as a creative force. To ask how different types of mutations impact evolutionary potential, we are using deep sequencing to monitor the competitive dynamics of spontaneous beneficial mutations in these populations and also engineering specific genomic changes. Systems biology and biochemistry approaches are used to link the effects of mutations on cell physiology to how they affect competitive fitness at the organism level, and bioinformatics and comparative genomics are used to investigate whether similar mutational pathways are important in nature.