Jan P. Stegemann is Professor and Associate Chair for Master’s Programs in the Department of Biomedical Engineering at the University of Michigan in Ann Arbor. He received BS and MS degrees in Chemical Engineering from the University of Toronto. Prior to earning his PhD in Biomedical Engineering from the Georgia Institute of Technology, Dr. Stegemann worked for five years at Boston-based W.R. Grace & Co., where his research focused on cell-based bioartificial organs. Dr. Stegemann’s current research focuses on the use of extracellular environments to control cell function and the development of engineered tissues. In particular, his laboratory develops matrices for cell-based therapies by creating composite materials of natural polymers, with main applications in musculoskeletal and vascular regeneration. Dr. Stegemann’s teaching interests are in the areas of biomaterials, tissue engineering, and medical product development.
Cell function is controlled by the totality of the 3D environment. In particular, the extracellular matrix (ECM) plays an important role in tissues by providing and regulating biochemical and mechanical cues that guide cell function. Our laboratory focuses on how cells interact with the 3D protein matrix around them, and how these interactions can be used to develop better biomaterials and engineered tissues. The biologically-derived proteins collagen and fibrin are of particular interest, due to their role as structural proteins in tissues and the range of effects that these polymers can have on cell function. We are developing composite biomaterials that combine the structural and biochemical features of these polymers, and which also incorporate other proteins that direct cell function
For more information please visit https://cmite.bme.umich.edu/