Charles Gersbach | AIChE

Charles Gersbach

Associate Professor
Duke University

Dr. Charles A. Gersbach is the Rooney Family Associate Professor at Duke University in the Departments of Biomedical Engineering and Orthopaedic Surgery, an Investigator in the Duke Center for Genomic and Computational Biology, and Director of the Duke Center for Biomolecular and Tissue Engineering.  His research interests are in genome and epigenome editing, gene therapy, regenerative medicine, biomolecular and cellular engineering, synthetic biology, and genomics.  Dr. Gersbach’s work has been recognized through awards including the NIH Director’s New Innovator Award, the NSF CAREER Award, the Outstanding New Investigator Award from the American Society of Gene and Cell Therapy, the Allen Distinguished Investigator award, and induction as a Fellow of the American Institute for Medical and Biological Engineering.


The Gersbach Lab is dedicated to applying innovative methods in molecular and genetic engineering to regenerative medicine, treating genetic disease, and enhancing our understanding of fundamental biological processes. In particular, our research aims to develop new technologies to modify genome sequences, epigenomic regulation, and cellular gene networks in a precise and targeted manner. These new technologies are then applied to correction of genetic diseases, directing cell differentiation, tissue regeneration, drug target discovery, or answering fundamental biological questions regarding gene regulation and genome structure and function. Examples of technologies used in our research include genome and epigenome editing with CRISPR/Cas9 and other DNA-targeting systems, protein engineering, directed evolution, genetic reprogramming, and optogenetics.

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