(316f) Self-Powered, Programmable, and Bioresorbable Drug Delivery Devices

Implantable drug delivery devices are powerful for localized and controlled pharmacological treatments. The emergence of bioresorbable materials in recent years presents an opportunity to develop bioresorbable drug delivery devices, which can naturally degrade and disappear in the human body after a period of operation. We will introduce an approach that allows programmable control over the self-powered drug release process in the form of a fully bioresorbable drug delivery device that combines electrochemically degradable valves and bioresorbable polymer reservoirs. Fully bioresorbable construction eliminates the need for secondary surgical removal processes after treatment. Lidocaine, a local anesthetics medicine, has been successfully released to the sciatic nerve in the rat animal model.