Optimization of the Synthesis of PLA Nanoparticles through Flash Precipitation

For the synthesis of Poly-Lactic Acid(PLA) nanoparticles, a method of nano-emulsion is used. This has often raised issue by taking a long time to create as well as inconsistent particle size and quality. In addition to the time limit, the emulsion method uses water, which can cause swelling of the particles. By using a method of nanoprecipitation, or flash precipitation, these issues are removed. Organic solvent and anti-solvent systems are applied instead which reduce the likelihood of the swelling of particles. By using solvents that are known to dissolve PLA, the anti-solvent can then be interchanged until the most optimal nanoparticle is achieved. This method has higher reproducibility as well as potential for scale up for larger batch sizes. The significance of these particles comes from their wide range of uses, but most notably as a drug-delivery method that can help deliver pharmaceuticals that aid in the fight against various kinds of cancers. The current primary purpose of these particles is to have them fight lung cancers by being delivered via inhaler straight to the lung, rather than through injection. This will then avoid the negative affects often experienced by the solvent that is often used for these therapeutics during treatment.