Biological Engineering

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Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

QbD for Generic Drugs: Oral Suspensions

AIChE Annual Meeting
Nov 7, 2010
The presentation will be focus on the approach for systematic development of oral suspensions. Suspension is a complex dosage form in which coarse...

Growth Kinetic Study of Chlorella Vulgaris

AIChE Annual Meeting
Nov 11, 2009
Algae are simple autotrophic organisms that produce complex organic compounds from simple inorganic molecules such as carbon dioxide using energy...

Stability and Reactivity of Enzymatic Papers

AIChE Annual Meeting
Nov 9, 2009
Bioactive papers and paper diagnostics are getting a reality for their low cost, selectivity and application flexibility. Critical is the thermal...

Advanced Biofuels - The Path Forward

AIChE Annual Meeting
Nov 8, 2009
Oil prices go up and they come down and our ability to forecast them with any real confidence has not been particularly good. A year ago when oil...

Biomass Thermal Conversion

AIChE Spring Meeting and Global Congress on Process Safety
Apr 29, 2009
Papers are on topics related sustatinable supply of a wide variety of biomass feedstocks to meet the needs of evolving liquid fuel demand (...

Advances in Biofuel Technologies

AIChE Spring Meeting and Global Congress on Process Safety
Apr 29, 2009
Papers on biodiesel production advances. Please Note : Advances in Biofuel Technologies -- Spring Meeting 2009 includes the following recorded...

Advances in Bioprocessing

AIChE Spring Meeting and Global Congress on Process Safety
Apr 29, 2009
Please Note : Advances in Bioprocessing -- Spring Meeting 2009 includes the following recorded presentations: · Biofuel and Biochemical Productions...

Avoid the Pitfalls of Bioprocess Development

August
2006
Process Development
Mukesh Doble
This article presents the challenges that an engineer might encounter when designing or scaling up bioprocesses and offers practical solutions, including those cited in literature.

Your Personal Genome for $1,000?

November
2009
SBE Special Section
IBM scientists from four fields — nanofabrication, microelectronics, physics and biology — are collaborating to develop a “DNA transistor” that could make obtaining a personalized genome analysis easier, faster, and cheaper — ultimately as low as $...

Biotransformations for a Green Future

October
2005
SBE Special Section
Susan Truesdell
Enzyme and microbial biotransformations offer green chemistry alternatives for performing difficult or non-selective chemical reactions.

Bioreactor Design for Chemical Engineers

August
2011
Back To Basics
Gregory T. Benz
Fermentation processes are based on chemical engineering principles. Understand these concepts to achieve optimal bioreactor design.

Deciphering the Mechanisms of Therapeutic Protein Production

October
2007
SBE Special Section
Christoph L. Bausch, Daniel W. Allison, Kevin J. Kayser, Matthew V. Caple, Trissa Borgschulte
Demand for therapeutic recombinant proteins will eventually exceed current production capabilities. This is a major driver in further understanding Chinese Hamster Ovary (CHO) cell biology, which is the cell line of choice for producing these...

Fermentation Goes Large-Scale

January
2003
Special Section
Alex Patist, Aristos Aristidou , J. J. Hahn , Pim van Hoek
Designing an economically competitive and environmentally sustainable fermentation route means considering the downstream separations needed to capture the final product during the initial process design.

Purifying Therapeutic Monoclonal Antibodies

May
2008
SBE Special Section
Amit Mehta, Amy Len, Benedicte Lebreton, Bradley Wolk, Jace Fogle, Martha Lovato Tse, Nuno Fontes, Robert van Reis, Roshan Shrestha
Eliminating the affinity chromatography step in the mAb purification process trims equipment requirements, shrinks the plant footprint— and reduces costs.

Principles of Bioprocess Control

November
2009
SBE Special Section
Joseph S. Alford
The use of complex living organisms, process variation, and lack of real-time measurements of key parameters are some of the challenges involved in automating a bioprocess. This article explains an indirect approach to monitoring and controlling a...

Enzyme Discovery: Screening, Cloning, Evolving

October
2005
SBE Special Section
Glenn Nedwin, Per Falholt, Thomas Schaefer
Enzymes are nature’s answer to many industrial and environmental challenges. This article details the latest approaches to enzyme discovery and evolution.

Biobutanol – A Replacement for Bioethanol?

August
2008
SBE Special Section
Ron Cascone
Ethanol, the leading incumbant biofuel, has several limitations.Butanol overcomes many of these, and holds promise as the next important transportation biofuel.

Integrating Single-Use Filtration Systems

January
2003
Special Section
Holly Haughney
Disposable filtration systems are gaiing popularity in the pharmaceutical arena. This article defines the equipment, specifications, applications and potential advantages of single-use filters and ancillary equipment.

Scaling Up Research to Commercial Manufacturing

November
2010
SBE Special Section
Erika Lapinskas
The production of stem-cell-based therapeutic products in large quantities is more complex than manufacturing molecular drugs. Scale-up and scale-out challenges arise related to the type of stem cell, cell expansion and banking, sterile handling,...

Mother Nature as both Doctor and Patient

November
2006
SBE Special Section
Edwin N. Lightfoot
Once we have grasped some essentials of this riotous, but surprisingly well ordered world, we shall find our transport phenomena background to have real utility.

The Role for Biofuels

March
2010
SBE Special Section
Carrie Atiyeh, Tim Eggeman
The advanced biofuels industry is at a critical stage of development and deployment.

Understand Discrete Nanoscale Transport

June
2008
On The Horizon
Anh-Tuan Dinh, Chinmay Pangarkar, Samir Mitragotri
Unlike mass, energy and momentum transfer, which are described by continuum equations, the movements and interactions of the nanoscale entitites within a cell constitute the transport phenomenon known as discrete nanoscale transport (DNT).

Consider Using Fluoropolymers in Biological Applications

December
2004
Materials
Lauri Jenkins, Sharon Libert, Victor Lusvardi
Even with the use of costly corrosion-resistant alloys, metal contamination continues to occur in the biologics industry, thus reducing product yield and activity. Fluoropolymers are emerging as a viable solution to this problem.

Bioprocess Design for a Novel Vaccine

November
2006
SBE Special Section
Barry C. Buckland
The challenges of vaccine development are not limited to identification of suitable antigens, adjuvants and delivery methods, but include regulatory, technical and manufacturing hurdles in translating a vaccine candidate to the clinic.

Metabolic Engineering of Next-Generation Biofuels

August
2008
SBE Special Section
James C. Liao, Wendy Higashide
Engineers are turning to genetic and biological tools and techniques to synthesize higher-chain alcohols that do not suffer from the same limitations as ethanol.

Minimize Scale-Up Risk

March
2010
SBE Special Section
Bertil Stromberg, J. Brad Cort, Thomas Pschorn
Proven commercial-scale equipment already exists for many operations involved in producing biofuels from lignocellulosic feedstocks.

Fulfilling the Promise of Nanomedicine

February
2006
SBE Special Section
Cristina Roman Vas, Rita D'Aquino with Tim Harper
Leveraging nanotechnology in the life science industries has given scientists new tools with which they have the potential to transform the world of medicine.

Industry and SBE News

October
2007
SBE Special Section
Dr. George Georgiou to Receive SBE's James E. Bailey Award; Averting an Epidemic— Novel Device Detects Avian Flu Virus in Less than Half an Hour; Cell-Free Protein Sythesis Comes of Age; Genetically Engineering Microorganisms into Pharmaceutical...

Supplemental Nanobiotechnology Tables

February
2006
SBE Special Section
These tables offer a snapshot of the many companies, research organizations and universities working in nanotechnology, nanoscience, nanobiotechnology and other variations of the term that has been coined to describe a revolutionary approach to...

Ionic Liquid Pretreatment

March
2010
SBE Special Section
Blake A. Simmons, Bradley M. Holmes, Harvey W. Blanch, Seema Singh
Ionic liquids show promise as lignocellulosic biomass solvents. But is this approach a scientific curiosity or a commercially viable biofuel pretreatment technology?

Engineering Organs: Heart and Esophagus

December
2007
SBE Special Section
Buddy D. Ratner
The potential for tissue engineering to transform the practice of medicine is enormous. Chemical engineers will play important roles in this revolution.

Speeding the Design of Bioprocesses

May
2008
SBE Special Section
Andrew D. Tustian, Sunil Chhatre
These experimental and modeling techniques enable the rapid, cost-effective design and scale-up of biopharmaceutical manufacturing in an integrated fashion.

Converting Cellulose to Biofuels

March
2010
SBE Special Section
David Hogsett, Eduardo Ximenes, Michael R. Ladisch, Nathan S. Mosier, Youngmi Kim
Biochemical and thermochemical process technologies being developed to convert wood and other lignocellulosic feedstocks to liquid fuels will drive the transition from corn-based ethanol to advanced biofuels.

Cancer's Newest Deadly Foe

February
2006
SBE Special Section
Suzanne A. Shelley
An array of nanoscale developments are poised to revolutionize cancer diagnosis and drug discovery efforts, and create new ways to target the delivery of potent, often toxic drug therapies, while reducing their dose-limiting side effects.

Bioprinting: Directed Tissue Self-Assembly

December
2007
SBE Special Section
Roger Markwald, Vladimir Kasyanov, Vladimir Mironov
Imagine eliminating patient waiting lists for organ transplants. Bioprinting holds the promise of making this happen, but, must research must be done first.

Keys to Bioreactor Selection

March
2002
Reactions and Separations
John A. Williams
A few basic types of bioreactor designs are used to produce a wide range of products, from antibiotics to foods to fuels. Here's how to pick the best options for your application.

Stem Cell Engineering 101

November
2010
SBE Special Section
Jonathan Monk
Stem cells are poised to transform medical treatments for a host of diseases and malignant conditions. Translating stem cell research into clinical therapies, disease models, and drug-screening platforms will require a combination of sound science...

Chemical Engineering in the Pharmaceutical Industry: R&D to Manufacturing

October, 2010
This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences...
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