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Stem Cell Engineering

Cell Therapy Bioprocessing

SBE Webinar
Feb 8, 2011
Jon Rowley, Peter Zandstra, Robert Deans

As cellular therapies are advancing through clinical development and getting closer to market, close collaborations between stem cell biologists, clinical cell processing technologists, and bioengineers will be required for effective commercializa

Molecular Elucidation and Engineering of Stem Cell Microenvironments

SBE Webinar
Jan 21, 2010

Stem cells are defined by their capacities for self-renewal and differentiation into one or more cell lineages, and these processes are regulated by signals from the stem cell microenvironment, or niche, in various tissues throughout organismal de

Stem Cell Engineering 101

November
2010
SBE Special Section
Jonathan Monk
Stem cells are poised to transform medical treatments for a host of diseases and malignant conditions. Translating stem cell research into clinical therapies, disease models, and drug-screening platforms will require a combination of sound science...

Engineering a Better Way to Heal Broken Bones

November
2010
SBE Special Section
Matthew B. Murphy
Integrating mesenchymal stem cells and biomaterials shows promise for treating traumatic skeletal injuries via bone tissue engineering.

Scaling Up Research to Commercial Manufacturing

November
2010
SBE Special Section
Erika Lapinskas
The production of stem-cell-based therapeutic products in large quantities is more complex than manufacturing molecular drugs. Scale-up and scale-out challenges arise related to the type of stem cell, cell expansion and banking, sterile handling,...

Developing Cell Therapy Biomanufacturing Processes

November
2010
SBE Special Section
Jon A. Rowley
Establishing scalable technology platforms that allow for varying levels of production throughout the different stages of clinical testing can minimize process development timelines, drug-comparability risks, and — ultimately — costs.
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