Biological Engineering

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From Biochemical Engineering to Synthetic Biology: A Short History of Engineering Impacts on Biotechnology

SBE Webinar

Sep 27, 2012

Harvey Blanch

This webinar will focus on how biochemical engineering developed in response to the need for large-scale production of antibiotics in the 1940s and 50s, even though fermentation provided a route to many industrial organic chemicals prior to their production from petroleum.

Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Food, Pharmaceutical & Bioengineering Division (FP & BE)

The FP&BE division coordinates AIChE's activities in the fields of food, pharmaceuticals, and bioengineering.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

Scaling up Strategy for Continuous Powder Mixing Process

Oct 19, 2011

Yijie Gao

Scaling up strategy for continuous powder mixing process Yijie Gao, Fernando Muzzio and Marianthi G. Ierapetritou Dept. of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854 Continuous powder mixing has attracted a lot of interest among pharmaceutical industry. Based on...

Towards Developing Anaerobic Digestion Based Biorefinery – Research On Food Wastes As Feedstock

Oct 19, 2011

Shulin Chen

Anaerobic digestion (AD) is a proven technology for waste treatment. However, as the organic material becomes more valuable and being treated as resources, traditional AD process is no longer adequate. The Bioprocessing and Bioproduct Engineering Laboratory at Washington State University has been...

Bioconversion of Brown Seaweed Into Mixed Ketones Through the Carboxylate Platform Processing

Oct 19, 2011

Xin Chen

The Carboxylate Platform, also known as the MixAlco TM process, is an acidogenic fermentation process using mixed culture inoculums, which offers several advantages compared to conventional bioprocessing, such as: non-sterile fermentation, the use of inexpensive tanks, adaptability to a wide...

Scale and Bioreactor Design Translation for Rocking Bag Bioreactors

Oct 19, 2011

John Bowers

Scale and Bioreactor Design Translation for Rocking Bag Bioreactors. The translations of scale and bioreactor designs for disposable rocking bag bioreactors are currently performed intuitively or with trial an error approaches. Conditions are typically based on manufacturer recommendations or...

Modeling a Reactive Crystallization with a Reduced Population Balance Equation for Dissolution and Growth to Control Critical Quality Attributes

Oct 19, 2011

Daniel Patience

Modeling has always been a powerful weapon in a chemical engineer’s arsenal. Use of modeling should be considered a key piece in the application of Quality by Design (QbD) in drug substance and drug product development. In this study, reaction, dissolution and growth kinetics are determined for a...

Quality by Design for DPIs -A Regulatory Perspective

Oct 19, 2011

Prasad Peri

Inhalation Powders have become an important dosage form in developing products for delivery to the lungs. Since the approval of the first DPI in the US in the late 1990’s there has been a rapid surge in the number of drug development programs involving Dry Powder Inhalers. The draft MDI/DPI...

The Role of Cellulose Accessibility On Enzymatic Saccharification of Lignocelluloses

Oct 19, 2011

Junyong Zhu

So much research has been dedicated to understand the effects of various factors on enzymatic hydrolysis of lignocelluloses. It has been understood that removal of hemicelluloses is very important to improve lignocellulosic substrate digestibility. It has also been identified that improving enzyme...

BIOCORE - On a Paradigm for the Design and Synthesis of Real-Life Biorefineries

Oct 19, 2011

Aikaterini D. Mountraki

As oil is a fast depleting resource (BP, 2010), much is expected by the production of biofuels as valid options to replace fossil-oil transportation fuels. Biorefineries are not an entirely new concept. Many of the traditional biomass conversion technologies such as the sugar and paper industries...

Effects of Reaction Conditions On the Acid-Catalyzed Hydrolysis of Miscanthus Dissolved In An Ionic Liquid

Oct 19, 2011

Sean J. Dee

Miscanthus, a perennial grass, is an attractive biofuel feedstock compared with corn and poplar due to its high energy yield per hectare and low agricultural inputs such as water and soil nutrients. Recent studies have shown the three primary components of miscanthus, cellulose, hemicellulose, and...

A Novel Reactive Distillation Approach for Producing 1,3-Dihydroxyacetone From Glycerol

Oct 19, 2011

Dennis J. Miller

Glycerol is a viable renewable feedstock that has emerged as a consequence of triglyceride conversion to biodiesel. In addition to glycerol conversion to commodity chemicals such as propylene glycol and epichlorohydrin, formation of higher-value specialty chemical products such as 1,3-...

Incorporating Computational Fluid Dynamics Methods for Quality by Design Framework for Exploring Design Space of a Fermentor

Oct 19, 2011

R. Muralikrishnan

In the Quality by Design (QbD) framework, there is a significant emphasis on the robust characterization of manufacturing processes and prospectively identifying the engineering design space that ensures product quality. Although the QbD approach is expected to bring about significant long-term...

Dissolution Testing of Prednisone and Salicylic Acid Calibrator Tablets At Different Tablet Locations

Oct 19, 2011

Piero M. Armenante

Dissolution testing is routinely carried out in the pharmaceutical industry to determine the rate of dissolution of solid dosage forms. This test is one of the several tests that pharmaceutical companies typically conduct on oral dosage formulations (e.g., tablets) to determine compliance. The USP...

An Anaerobic Bacterial Treatment of Corn Stover to Prepare a Biorefining Feedstock

Oct 19, 2011

James MacLellan

Anaerobic Bacterial Treatment of Corn Stover to Prepare a Biorefining Feedstock James MacLellan, Zhengbo Yue, Robert Kraemer, Wei Liao* Department of Biosystems and Agricultural Engineering, Michigan State University East Lansing, Michigan 48823 Abstract The objective of this study is to apply an...

Change of Structure of Corncob with Dilute Acid and Lime Pretreatment and a Potential Process for Xylose Co-Production of Cellulosic Ethanol

Oct 19, 2011

Jihong Li

Degree of polymerization (DP) of cellulose is considered an important factor to effect on the conversion of Lignocellulose. The higher DP of cellulose, the more difficult conversion of lignocellulose is. In this study, corncobs were pretreated with dilute acid process for production of xylose, and...

Green and High Efficient Enzyme Hydrolysis Process for Sweet Sorghum Bagasse

Oct 19, 2011

Xinshu Zhuang

In order to improve enzymatic hydrolysis efficiency, several approaches including liquid hot water (LHW) pretreatment, adding surfactant, magnetic stirring and fed-batch hydrolysis were investigated, in which Sweet sorghum bagasse (SSB) was chosen as the feedstock. The experiment results showed...

Design Space Definition Using a Variational Bayes' Approximation

Oct 19, 2011

Linas Mockus

The design space may be interpreted as the constrained region of the key manufacturing parameters space which provides assurance of quality of a drug given that manufacturing occurs in this region. The metric used to represent this assurance should not be deterministic, rather it should be stated...

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