Biological Engineering

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Society for Biological Engineering (SBE)

SBE is a global technological community that promotes the integration of engineering with biology and realize its benefits through bioprocessing, biomedical, and biomolecular applications. SBE provides opportunities for interaction of engineers and scientists, develops products and services bring value to the broad biological engineering community, and infuses awareness of biological engineering among all functions and activities of AIChE.

Forest Bioproducts Division (FBP)

The Forest Bioproducts Division promotes knowledge sharing and networking on topics dealing with products obtained from forest resources and other lignocellulosic materials.

Application of QbD Principles to Analytical Methods

Conference Presentation
AIChE Annual Meeting
Sunday, November 8, 2009 - 7:00pm
The same QbD Principles applied to the design of manufacturing processes are applicable to the design of analytical methodology. QbD elements such as...

Update on QbD Implementation: An FDA Perspective

Conference Presentation
AIChE Annual Meeting
Sunday, November 8, 2009 - 7:00pm
Quality by Design (QbD) is a science and risk based approach for pharmaceutical process development and manufacturing that begins with first defining...

Drug Product Quality by Design: An Industrial Perspective

Conference Presentation
AIChE Annual Meeting
Sunday, November 8, 2009 - 7:00pm
The regulatory quality guidances (Q8 – Q10) have set the expectation to develop pharmaceutical products based on a comprehensive quality by design...

Biomass Thermal Conversion

Conference Presentation
AIChE Spring Meeting and Global Congress on Process Safety
Wednesday, April 29, 2009 - 10:00am
Papers are on topics related sustatinable supply of a wide variety of biomass feedstocks to meet the needs of evolving liquid fuel demand (...

Advances in Bioprocessing

Conference Presentation
AIChE Spring Meeting and Global Congress on Process Safety
Wednesday, April 29, 2009 - 4:30am
Please Note : Advances in Bioprocessing -- Spring Meeting 2009 includes the following recorded presentations: · Biofuel and Biochemical Productions...

Success and Prospects in Bioengineering

Conference Presentation
AIChE Annual Meeting
Sunday, November 16, 2008 - 7:00pm
Chemical engineers have always played an important role in the development of biotechnology. From the first efforts to effectively produce penicillin...

Society for Biological Engineering News

October
2005
SBE Special Section
June Wispelwey
Student Chapters Have Arrived! SBE Frontier Tutorial Second Bioengineering and Nanotech Conference Michael Shuler Wins Inaugural James E. Bailey Award Fishing Out Unusual DNA Enzyme is Linked to Neurological Disease

Biotransformations for a Green Future

October
2005
SBE Special Section
Susan Truesdell
Enzyme and microbial biotransformations offer green chemistry alternatives for performing difficult or non-selective chemical reactions.

Enzyme Discovery: Screening, Cloning, Evolving

October
2005
SBE Special Section
Per Falholt, Glenn Nedwin, Thomas Schaefer
Enzymes are nature’s answer to many industrial and environmental challenges. This article details the latest approaches to enzyme discovery and evolution.

Technical Entity Trends: Welcome to the TENT

January
2016
Technical Entity Trends
Lucy Alexander, Derrick Wu
Welcome to Technical Entity Trends (TENT), a new monthly CEP column written by the staff of AIChE’s Technical Entities (TEs). The TEs are communities of chemical engineers and other professionals that address some of society’s grand challenges:...

Bioreactor Design for Chemical Engineers

August
2011
Back To Basics
Gregory T. Benz
Fermentation processes are based on chemical engineering principles. Understand these concepts to achieve optimal bioreactor design.

Green Chemistry and Engineering: A Pathway to Sustainability

November, 2013
Green Chemistry and Engineering presents the green approach as an essential tool for tacking problems in chemistry. This text covers introductory concepts in general, organic, inorganic, and analytical chemistry as well as biochemistry.

SBE Update: The Merging of Bio and Nano

December
2012
SBE Special Section
June Wispelwey
Earlier this year, the Society for Biological Engineering (SBE) organized its Sixth International Conference on Bioengineering and Nanotechnology (ICBN), which focused on bio-nanoscience and bioengineering for translational medicine. The conference...

Bioactive Devices: Uniting Form with Function

March
2013
SBE Special Section
Sujata Bhatia
Bioactive implants that combine a medical device with one or more biologic therapeutic agents show promise for the targeted treatment of complex medical conditions. Implantable medical devices, such as stents, grafts, and joint replacements, are...

Bio-Based Materials in the New Bio Economy

May
2012
SBE Special Section
Manjusri Misra, Amar Mohanty, Murali M. Reddy
Biological feedstocks are expected to gradually replace some fossil-based raw materials to create eco-friendly products, from car parts and packaging materials to electronic devices and other consumer goods - laying the foundation for a reduced-carbon economy.

Producing Fuels and Chemicals from Lignocellulosic Biomass

August
2008
SBE Special Section
Mark Holtzapple, Rocio Sierra, Aaron Smith, Cesar Granda and Mark T. Holtzapple
As oil and natural gas prices rise, lignocellulosic biomass becomes a viable feedstock for the fuel and chemical industries— provided key issues are addressed.

A MagDot-Nanoconveyor Assay Detects and Isolates Molecular Biomarkers

December
2012
SBE Special Section
Jeffrey Chalmers, Maryam B. Lustberg, M.D., Kalpesh Mahajan, Brandon Miller, Gang Ruan, Ratnasingham Sooryakumar, Gregory B. Vieira, Jessica Winter
The ability to quickly analyze, separate, and manipulate multiple types of biomarkers from small sample volumes is a significant step toward personalized medicine.

SBE Special Section: Biopharmaceuticals - SBE Update: Continuous Progress in Biopharmaceuticals

December
2015
SBE Special Section
Darlene Schuster
The goal of bioprocessing is to optimize natural or artificial biological systems by manipulating prokaryotic and eukaryotic cells and their environment to produce biopharmaceutical products. A bioprocess is divided into upstream and downstream operations. Upstream processing encompasses the steps from preliminary unmodified cell line culture to the mature modified cell culture and harvest; downstream processing includes the separation and purification of the biologics from the mature activated cell culture. These operations have typically been performed as batch processes.

SBE Update: Drug Delivery and Chemical/Biological Engineering

March
2013
SBE Special Section
June Wispelwey
Although you might not associate drug delivery with chemical engineering, the principles of chemical engineering — such as mass and energy balances, transport phenomena, reaction kinetics, and particle technology — are intimately involved in drug...

SBE Supplement: Biochemical Engineering - Cell-Free Bioprocessing

November
2013
SBE Special Section
James Swartz
The ability to exploit a cell’s contents and capabilities unimpeded by cell walls opens new opportunities for the field of biochemical engineering. Cell-free biology could become the basis for making products from hydrogen to cancer vaccines and more.

Engineered Protein Templates Synthesize Inorganic Nanomaterials

December
2012
SBE Special Section
Arunagirinathan Adhimoolam, Sarah Heilshorn, Kelly N. L. Huggins, Alia Schoen, David T. Schoen
This powerful biomimetic method is a fast, flexible way to produce a wide range of inorganic nanostructures from a single protein scaffold.

Biology as a Basis for Biochemical Engineering

July
2013
Back To Basics
Sujata Bhatia
Biochemical engineering demonstrates the versatility of the living cell as a miniature reactor. Living cells can be genetically engineered to produce specific proteins, tuned to manufacture novel enzymes, and optimized to guarantee genetic stability and consistent production of desired products.

SBE Special Section: Biopharmaceuticals - Continuous Processing in Downstream Operations

December
2015
SBE Special Section
Todd Przybycien, Professor Nigel Titchener-Hooker
The transition from batch to continuous downstream processing of biologics has been gradual, with some processes integrating continuous and batch operations. A fully continuous, commercial-scale downstream process has yet to be implemented. Find out why, as well as the current status of the technology.

Using Genomic Tools to Improve the Production of Biologics

November
2009
SBE Special Section
Dr. Wei-Shou Hu, Nitya M. Jacob, Wei-Shou Hu, Bernard Liat Wen Loo, and Miranda Yap
Recombinant DNA technology transforms mammalian cells into factories for protein-based therapeutics. New techniques provide chemical engineers with a better understanding of the process as well as the cells themselves.

Algal Biofuels: The Research

March
2011
SBE Special Section
Kuan-Chen Cheng, Kimberly Ogden
The individual technical elements of the algae-to-biofuels process have already been demonstrated at the laboratory scale. Ongoing research seeks to refine the technology to enable scaleup to commercial production.

Recombinant Protein Therapeutics from CHO Cells -- 20 Years and Counting

October
2007
SBE Special Section
Dr. Wei-Shou Hu, Karthik P. Jayapal, Katie F Wlaschin, Wei-Shou Hu and Miranda G. S. Yap
The CHO cell is at its height of technological prominence thanks to its adaptability to various culture conditions and plasticity in the context of genetic alterations. With further research, the application ofCell Culture Strategies based on...

SBE Special Section: Biopharmaceuticals (Full 19-Page Supplement)

December
2015
SBE Special Section
Chun Chen, Chetan T. Goudar, Huong Le, Todd Przybycien, Nigel Titchener-Hooker
SBE Update: Continuous Progress in Biopharmaceuticals; Continuous Processing in Upstream Operations; Continuous Processing in Downstream Operations; A Look at the Regulations

Synthetic Biology: Putting Together the Pieces

July
2015
On The Horizon
Michelle Bryner
Synthetic biology represents a new way of building biological systems via engineering tools and principles. Genetic components and pathways will be created to reprogram organisms, endowing them with novel functions for a wide range of applications.

New Products: December 2015

December
2015
New Products
Instrumentation Temperature Transmitters Feature Dual Sensor Inputs The THZ 3 and TDZ 3 two-wire (loop-powered) temperature transmitters provide an isolated and linear 4–20-mA output proportional to input. They can be configured quickly and easily...

The Blood-Brain Barrier and Drug Delivery

March
2013
SBE Special Section
William Olbricht
To maintain favorable conditions in the brain, the blood-brain barrier limits mass transfer across brain tissue. However, it also restricts the systemic delivery of compounds to treat neurological disorders. Several treatment alternatives to bypass...

SBE Special Section: Lignocellulosic Biofuels - Full 32-Page Supplement

March
2015
SBE Special Section
Tristan R. Brown, Robert Brown, Sergio C. Capareda, Bruce E. Dale, David Edwards, Vonnie Estes, Cesar Granda, Mark Holtzapple, Sagar Lonkar, Darlene Schuster, Charles Wyman
SBE Update; The Need for Biofuels; Producing Biofuels via the Thermochemical Platform; Producing Biofuels via the Sugar Platform; Producing Biofuels via the Carboxylate Platform; Scaling Up Bioenergy Technologies; Commercial-Scale Production of Lignocellulosic Biofuels

CEP: News Update

August
2015
News Update
Sponge-Like Catalyst Makes Bioplastic Cheaper and Greener; LED Combines Optoelectronic Powerhouses; New Water Splitter Produces Hydrogen; Algal Fuel Gets a Boost; and more.

CEP: News Update

July
2015
News Update
Inks from Silk Show Biomedical Promise; Activated Carbon Gets a Designer Label; Graphene Coating Promises to Improve Condenser Efficiency; Solar Materials Self-Assemble for Lengthy Energy Storage; and more.

CEP: News Update

May
2015
News Update
Metabolic Engineering Delivers Low-Cost Hydrogen; Metal-Free Catalyst Recharges Zinc-Air Batteries; Aluminum Could Take Charge of the Battery Market; New Desalination Membrane Resists Chlorine; and more

CEP: News Update

April
2015
News Update
Chameleon-Like Material Changes Color On Demand; New Genes for an Old Microbe Make Statins Cheaper; A Sweet Approach to Breaking Down Cellulose; New Catalyst Pushes Lignin Up on the Value Chain; and more.

CEP: AIChE Journal Highlight - Layer-by-Layer Approach Enables Customizable Medication Therapy

April
2015
Journal Highlight
In the April AIChE Journal Perspective article, “Layer-by-Layer Approaches to Staging Medicine from Surfaces,” Paula T. Hammond of the Massachusetts Institute of Technology describes her research on a method that creates layers of thin films stacked on top of one another. Each layer contains a different therapeutic, which is incorporated into the thin film via one of several mechanisms (e.g., charge, hydrogen bonding, or other complementary interaction). This technique is useful for drug therapy in applications such as bone regeneration.

Singapore: An Emerging Leader in Biomedical Sciences

October
2007
SBE Special Section
Niki S. C. Wong, Miranda G. S. Yap
With a heavy investment in biomedical research— particularly the $330 million to build Biopolis in 2003— Singapore is seeing the fruits of its labor blossom.

CEP: News Update

March
2015
News Update
Cheap and Abundant Potassium Outperforms Precious Metal Catalyst; Engineering Bioethanol without the Food Gap; Supercomputers Identify Optimal Zeolites; Synthetic Biology Pushes Gene Therapy Forward; and more.

CEP: News Update

December
2014
News Update
Fossil Fuels Inspire Clean-Hydrogen Catalyst; Organic Solar Cells Heat Up; Biomass Waste Gets Upgraded; New Technique Puts Catalysts on the Right Track; and more.

CEP: News Update

November
2014
News Update
AIChE’s Initial Placement Survey: Where is the Class of 2014?; Producing More Ethanol with Less-Sensitive Microbes; Stretchable Patch Provides First-Class Health Monitoring; New Drug Capsule Takes the Ouch Out of Injections; Hybrid Device Combines a Solar Cell and a Battery.

CEP: News Update

October
2014
News Update
Tiny Assembly Line Builds Organic Molecules One Side Group at a Time; Engineered Microbes Synthesize Bio-Propane; Buckyballs Boost Organic Solar Cell Efficiency; Masquerade Ball: Squid Skin Inspires a New Material; A Microbial Approach to Pain Management; Phase Change: Liquid Battery for Grid-Scale Storage; and more.

CEP: News Update

September
2014
News Update
The Science Behind the Breakthrough Ebola Treatment; Polymers Crystallize into Zeolite-Like Structures; Magnetic Attraction: New Material Guides Fluid Flow; MoS2 Pushes Graphene Aside for Fast DNA Sequencing; and more.

CEP: News Update

July
2014
News Update
Nanoparticles Detect Sulfur Content in Crude Oil; Putting Waste Heat to Work; New Process Prints Personalized Drugs; EPA to Cut CO2 from Power Plants; Microbes Convert Biodiesel Waste into Valuable Chemicals

CEP: News Update

October
2013
News Update
Crunching the Numbers on Grid-Scale Storage; Microbes Convert Waste into Electricity; Solar Cells Make the Right Connection; Engineered Tissue Mingles with Blood Vessels; and more.

CEP: Catalyzing Commercialization - Living Plants: One-Stop Shop for Protein Manufacturing

July
2014
Catalyzing Commercialization
Chemical manufacturing facilities housing green plants perform all of the processes formerly handled by stainless steel equipment. Production is energy efficient, fueled by photosynthesis, as living plants secrete raw materials (e.g., high-purity spider silk proteins) for downstream production and processing. Thanks to Wisconsin-based ag-biotech startup PhylloTech, this surreal vision may not be so far-fetched.

CEP: News Update

May
2014
News Update
Stick-On Health Tracker Twists, Stretches, and Bends; No Corn Needed: Ethanol Is Produced from CO; Engineered Bacteria Turn Switchgrass into Jet Fuel; Reversing Evolution Promises Cheaper Pharmaceuticals; and more.

CEP: News Update

March
2014
News Update
Silicon Anode Gets a Fruity Makeover; New Anode Provides a Home for Plus-Sized Na+ Ions; A Flicker of Hope for Nonflammable Li-Ion Batteries; Bio-Inspired Glass Is Bendable; and more.

CEP: News Update

January
2014
News Update
Harmless Virus Helps Assemble Li-O2 Cathode for Batteries; A Sticky Solution for Tissue Engineering; Biopatch Catalyzes Bone Regeneration; Shape-Shifting Material Heats Up; and more
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