Pharmaceuticals (Chemicals & Materials)

Scaling-Up in Supercritical Fluid Chromatography

Conference Presentation
AIChE Annual Meeting
Thursday, November 7, 2013 - 9:45am-10:15am
Supercritical fluid chromatography (SFC) is already recognized as the method of choice for the preparative separation of chiral molecules in...

Complex Fitness Diagrams and Downstream Processing

Conference Presentation
AIChE Annual Meeting
Tuesday, November 5, 2013 - 10:15am-10:30am
Focus here is development of production scale processes and specifically with modifying optimized laboratory processes that are unsuitable for large-...

On the Modeling of Oral Drug Delivery

Conference Presentation
AIChE Annual Meeting
Thursday, November 1, 2012 - 12:30pm-1:00pm
On the Modeling of Oral Drug Delivery Naresh Pavurala, Luke E.K Achenie Department of Chemical Engineering, Virginia Polytechnic Institute and State...

Automation and Control of Drug-On-Demand Technology

Conference Presentation
AIChE Annual Meeting
Wednesday, October 31, 2012 - 5:15pm-5:45pm
Stimulated by initiatives such as PAT and QbD, the pharmaceutical industry has been focusing on the development of innovative, efficient...

A QbD Approach to the Process Development of Tofacitinib

Conference Presentation
AIChE Annual Meeting
Wednesday, October 31, 2012 - 1:15pm-1:30pm
Tofacitinib citrate (CP-690,550-10) is currently being evaluated for the treatment of rheumatoid arthritis, psoriasis and other diseases. An NDA has...

A Novel QbD Tool for Statistical Data Analysis

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 10:15am-10:30am
One of cornerstones of Quality by Design (QbD) is Design of Experiments (DoE). However, in addition to DoE, ICH Q8 (R2) recommends an enhanced...

Algae - The New Green Crude

Archived Webinar
Mar 1, 2012
Algae provides one solution to help the US reduce its dependence on foreign oil and create new green jobs. Barry Cohen and Will Thurmond will discuss...

Bio-Based Materials Step into the Operating Room

September
2012
On The Horizon
Sujata K. Bhatia, M.D., P.E.
A new class of implantable medical materials — constructed from naturally derived and renewably sourced polymers — is poised to transform clinical medicine.

Using Automation to Produce Quality Pharmaceuticals

October
2011
Instrumentation
Joseph S. Alford, P.E.
Automation can pay large dividends in the form of reduced process cycle times, lower operational costs, and more-consistent processes for manufacturing high-quality pharmaceutical products.

SBE Update

July
2009
SBE Special Section
June Wispelwey
Improving Biopharmaceutical Development

Properly Select Equipment for SIP Systems

August
2007
Fluids and Solids Handling
Tony George
Sterilization-in-place (SIP) systems are essential to the operation of many pharmaceutical and biotech facilities. This article reviews design considerations, selection criteria and performance expectations for control valves, regulators, isolation...

An Introduction to Immunity and Vaccines

November
2011
SBE Special Section
Derek Lapiska
An understanding of the basic approach to creating vaccines, as well as how vaccines confer immunity, is essential to developing safe and cost-effective formulations.

Selecting Agitator Seals for Bioprocessing Applications

January
2008
Fluids and Solids Handling
William Ho Liam Teng, Gregory T. Benz
Issues such as sterility, isolation and contamination must be considered when choosing seals for use in biotech and pharmaceutical processes. This overview describes common types of seals and offers guidance on selecting the appropriate seal for...

Good Drug Therapy: It's Not Just the Molecule - It's the DELIVERY

February
2004
Special Section
Rita D'Aquino
In today's competitive marketplace, biopharmaceutical companies are seeking effective and user-friendly drug-delivery platforms for their drug molecules. Miniaturized, microfabricated and nanofabricated devices that can be implanted in the body are...

Chemical Engineering Perspectives on Vaccine Production

November
2011
SBE Special Section
Jose M. Otero, Bret R. Phillips, Michael E. Laska, John G. Aunins
Fundamental chemical and bioprocess engineering principles and tools will be key to developing and manufacturing vaccines and expanding their availability around the world.

Rx for Pharma

March
2009
Critical Issues
Girish Malhotra, P.E.
Chemical engineers could hold the key that helps pharmaceutical companies — facing pressure to control rising drug prices and competition from generics — reduce their manufacturing costs.

Understand Flow Patterns in Glass-Lined Reactors

November
2004
Reactions and Separations
Keith E. Johnson , Christopher J. Ramsey, Kevin J. Bittorf, David S. Dickey
Physical modeling and computer simulation provide insights into the performance of a glass-lined reactor.

Exploring New Paradigms for Bioprocessing

July
2009
SBE Special Section
Jonathan Monk
Disruptive technologies, such as disposable bioreactors, metabolic ?ux models, and glycoengineered yeast, could change the face — and pace — of biomanufacturing.

Designing a Facility for API Development

March
2006
Plant Design
Yasha Zelmanovich, Terrence Fay
Kilo labs are instrumental in scaling up the production of active pharmaceutical ingredients. This article discusses the critical factors that must be considered to design such a facility.

Streamlining the Validation Process

March
2007
Management
Robert Mackey, Tim Flanigan
Today, validation is no longer an afterthought for the design and construction of a new or renovated process or facility. It is, in fact, recognized as an integral part of the total project. Fully integrated services are now available to ensure a...

Chemical Engineering in the Pharmaceutical Industry: R&D to Manufacturing

October, 2010
This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences...
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