A feed-forward process control strategy which can compensate for the effect of raw material lot-to-lot variability on final tablet attributes in pharmaceutical tablet development is presented. The approach involves building PLS (partial least squares) models that combine raw material attributes and tablet process parameters to relate these to final tablet attributes. Prior to a manufacturing batch, the resulting models are used in an optimization framework to find optimal process conditions which can satisfy desired final tablet attributes while taking into account the attributes of specific raw material lots used in the batch. The effectiveness of the methodologies is illustrated through an industrial tablet manufacturing case study.&'
Would you like to access this content?
No problem. You just have to complete the following steps.
You have completed 0 of 2 steps.
You must be logged in to view this content. Log in now.
Purchase Technical Presentation
You must purchase this technical presentation using one of the options below.
If you already purchased this content recently, please click here to refresh the system's record of ownerships.
|Credits||0.5 Use credits|
|List Price||$25.00 Buy now|
|AIChE Members||$15.00 Buy now|
|AIChE Undergraduate Student Members||Free Free access|
|AIChE Graduate Student Members||$15.00 Buy now|