2006

Succeed at Catalyst Scale-Up

June
2006
Reactions and Separations
Ben Wagner, Donald R. Engelbert, J. Todd Osbourne, Jeff Braden, Richard Allen, Uday T. Turaga, William H. Beever
Follow these principles to reduce the time required for scale-up and commercialization to improve the resource effectiveness of the effort.

Understand Temperature Change in Process Stream Mixing

September
2006
Heat Transfer
Anil K. Mehrotra, Dharmendra Tiwary
The isobaric and adiabatic mixing of process streams can yield an outlet stream temperature that is either in between, higher than, or lower than the inlet stream temperatures. This article uses simulation to explore temperature-change scenarios in...

Optimizing Batch Operations

January
2006
Reactions and Separations
Kah Loong Choong, Robin Smith
Use this novel method to optimize the operating conditions as they vary through time in batch processes.

Use Cascade Analysis to Optimize Water Networks

July
2006
Environmental Management
Dominic Chwan Yee Foo, Yin Ling Tan, Zainuddin Abdul Manan
This numerical technique for identifying fresh water and wastewater targets eliminates the tedious and time-consuming steps of graphical targeting approaches. Use it to complement the graphical techniques in the design and retrofit of water networks.

Pipeline Pressure Drop: A New Design Correlation

June
2006
Fluids and Solids Handling
Roger Gilmont
A linear equation has been derived to accurately calculate the flowrate of fluids in the laminar and turbulent regions, and to derive an equation for use in the transitional regions.

Fulfilling the Promise of Nanomedicine

February
2006
SBE Special Section
Cristina Roman Vas, Rita D'Aquino with Tim Harper
Leveraging nanotechnology in the life science industries has given scientists new tools with which they have the potential to transform the world of medicine.

Building Models from Simulator Runs

January
2006
Computational Methods
Aad van Veldhoven, Magali de Macedo
The design-of-experiments approach has the advantage of providing the framework to build complex models with minimum use of time and effort.

Designing a Facility for API Development

March
2006
Plant Design
Terrence Fay, Yasha Zelmanovich
Kilo labs are instrumental in scaling up the production of active pharmaceutical ingredients. This article discusses the critical factors that must be considered to design such a facility.

Mother Nature as both Doctor and Patient

November
2006
SBE Special Section
Edwin N. Lightfoot
Once we have grasped some essentials of this riotous, but surprisingly well ordered world, we shall find our transport phenomena background to have real utility.

Right-Sizing Environmental Controls

June
2006
Environmental Management
E. Joseph Duckett
Size does matter - and bigger is not necessarily better when it comes to pollution control. It is more important to be the right size than the largest size.

Industrial-Scale Flare Testing

May
2006
Environmental Management
Charles Baukal, Jianhui Hong, Mahmoud Fleifil, Robert Schwartz
Advanced flare testing at full scale can help to ensure that the system operates as designed. This article explains what's involved and the parameters that should be measured and evaluated to demonstrate performance, reliability and safety.

Simplify Wastewater Treatment Process Design

January
2006
Environmental Management
Apostolos Vlyssides, Elli Maria Barampouti, Sofia Mai
Unlike time-consuming conventional methods, this approach to designing a dissolved air flotation (DAF) plant requires only the physical characteristics of the flocs — their size and density, flowrate and temperature.

Avoid the Pitfalls of Bioprocess Development

August
2006
Process Development
Mukesh Doble
This article presents the challenges that an engineer might encounter when designing or scaling up bioprocesses and offers practical solutions, including those cited in literature.

Who Done It? The ABCs of Environmental Forensics

March
2006
Environmental Management
Jeffrey Bolin, Matthew Schroeder, Michael Sklash
These tools and techniques can be used to make sense of soil or groundwater contamination - where it came from, who is responsible for it, and how to fairly allocate the costs to clean it up.

Bioprocess Design for a Novel Vaccine

November
2006
SBE Special Section
Barry C. Buckland
The challenges of vaccine development are not limited to identification of suitable antigens, adjuvants and delivery methods, but include regulatory, technical and manufacturing hurdles in translating a vaccine candidate to the clinic.

Fundamentals of Effective Leadership

June
2006
Career Catalyst
Richard J. Kinsley
To become a leader people want to follow, focus on the team's objectives, avoid self-deception, build strong relationships, and enable others to achieve the team's goals.

Cancer's Newest Deadly Foe

February
2006
SBE Special Section
Suzanne A. Shelley
An array of nanoscale developments are poised to revolutionize cancer diagnosis and drug discovery efforts, and create new ways to target the delivery of potent, often toxic drug therapies, while reducing their dose-limiting side effects.

Reduce Business Risk with a CMS

October
2006
Environmental Management
Robert F. Boland
A compliance management system (CMS) helps companies meet regulatory reporting requirements, improve environmental performance, reduce environmental compliance costs, and increase organizational efficiency. Here's a run-down of what to look for when...
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