Chemical Engineering Practice

Application of Quality by Design in API Process Development

Conference Presentation
AIChE Annual Meeting
Wednesday, October 31, 2012 - 2:45pm-3:00pm
Design of Experiments (DOE) is the most effective method to achieve product and pro­cess efficiency and optimization. Design of Experiment (DOE)...

Dry Reforming of Methane Using Rh Substituted Pyrochlores

Conference Presentation
AIChE Annual Meeting
Wednesday, October 31, 2012 - 1:15pm-1:30pm
Dry (CO 2 ) reforming of methane (DRM) to syngas (H 2 and CO) has been well-studied over a number of catalysts. The high temperatures needed to...

A QbD Approach to the Process Development of Tofacitinib

Conference Presentation
AIChE Annual Meeting
Wednesday, October 31, 2012 - 1:15pm-1:30pm
Tofacitinib citrate (CP-690,550-10) is currently being evaluated for the treatment of rheumatoid arthritis, psoriasis and other diseases. An NDA has...

Engineering Pellets of Biomass Blends

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 3:15pm-3:45pm
Transportation and handling of lignocellulosic biomass are often challenging and expensive due to low bulk density, in the range of 60-80 kg/m 3 for...

Fuel Processing: Renaissance of the Second Decade (Keynote)

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 3:15pm-3:45pm
The early development of fuel processing technologies for fuel cell systems was, to a great extent, driven by fuel cell automobile programs. At the...

Post-Combustion Gas Permeation Carbon Capture System Models

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 2:45pm-3:00pm
Post-Combustion Gas Permeation Carbon Capture System Models Juan E. Morinelly, David C. Miller National Energy Technology Laboratory (NETL) Gas...

Insights From Glucose Pyrolysis for Cellulose Pyrolysis

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 1:30pm-1:45pm
Experimental and predicted kinetics of glucose, the monomer of cellulose, provides quantitative and qualitative insights into the pyrolysis of...

Optimal Design of Transient Microreactor Experiments

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 12:30pm-1:00pm
Development of synthetic routes for active pharmaceutical ingredient (API) synthesis is increasingly performed using microreactors, because their use...

A Novel QbD Tool for Statistical Data Analysis

Conference Presentation
AIChE Annual Meeting
Tuesday, October 30, 2012 - 10:15am-10:30am
One of cornerstones of Quality by Design (QbD) is Design of Experiments (DoE). However, in addition to DoE, ICH Q8 (R2) recommends an enhanced...

Modelling of a Filter Drying Process

Conference Presentation
AIChE Annual Meeting
Monday, October 29, 2012 - 5:15pm-5:45pm
Filter drying, also referred to as vacuum contact drying, is a process widely used in the pharmaceutical industry to remove water or organic solvents...
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