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Synthetic Biology

The Other Bio: Chemicals and Materials

May
2012
SBE Special Section
Miriam Cortes­ Caminero
Just in case you haven’t noticed, a new wave of biotechnology is underway. Over the last three decades, we have seen biological technologies used in therapeutics and agriculture. More recently, we have seen the use of biotechnology for industrial purposes.

 A Microrna Based Synthetic Network as Stable Expression Unit in Mammalian Cells

Nov 7, 2010
Leonidas Bleris
The utility and scalability of complex synthetic gene networks is hampered by fluctuations in stoichiometry between different gene products in individual cells. A critical contribution to the fluctuations arises from variation in the basic transcription efficiency of a gene product that in turn is...

Systems Biology and Synthetic Biology

March, 2009
The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems...

Success and Prospects in Bioengineering

Nov 16, 2008
Harvey Blanch
Chemical engineers have always played an important role in the development of biotechnology. From the first efforts to effectively produce penicillin on a large scale to the newest advances in drug delivery, chemical engineers have been working hand in hand with biologists. In his lecture,...

Stochastic Simulations of the Tetracycline Operon

Nov 9, 2010
Konstantinos Biliouris
The tetracycline (tet) operon is a robust self-regulated system. It is found naturally in bacteria where it confers resistance to antibiotic tetracycline. Because of the performance of the molecular elements (promoters, operators, repressor) of the tetracycline operon, these elements are widely...

Automated Metabolic Network Reconstruction: Method, Application and Web Tool

Nov 8, 2010
Yu Chen
Genome-wide metabolic network reconstruction has proved to be a powerful tool for system-level study of whole-cell metabolisms. A great amount of efforts have been spent in reconstructing metabolic networks of a few tens of organisms, including bacteria, archaea and eukaryotes. However, it remains...

Novel, Synthetic, Tetracycline-Inducible Transcription Regulators for E. Coli

Nov 7, 2010
Katherine G. Volzing
We are designing, constructing and characterizing novel synthetic gene regulators. These regulators range from individual inducible fusion protein and promoter pairs to complex nonlinear regulatory networks. All of the regulators are designed to be compatible in E. coli and to control gene...
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