Spray Drying Process Design: Establishing Links Between Process Parameters and Product Performance

Comprehensive Quality by Design in Pharmaceutical Development and Manufacture
2010 AIChE Annual Meeting
AIChE Annual Meeting
November 10, 2010 - 7:00pm
Spray drying or spray congealing is typically used to manufacture a powder for further processing into a final dosage form. Although this operation can profoundly influence the properties and quality of the final product, its contribution is subtle and often incompletely understood due to the impact of subsequent processing steps. Inability to adequately characterize the relationships between the drying or congealing process and the final product can lead to difficulties establishing process and product robustness and reproducibility during late-stage development and scale up. This presentation will provide an overview of how, through a systematic design space and risk assessment approach, key relationships between the powder generation process and the final product have been successfully captured and used to facilitate late-stage development efforts. Two examples are included to illustrate this approach in design of a direct compression tablet and an enteric coated particle blend.
Professional Development Hours
0.5 PDHs
You will be able to download and print a certificate for these PDH credits once the content has been viewed. If you have already viewed this content, please click here to login.

Would you like to access this content?

No problem. You just have to complete the following steps.

You have completed 0 of 2 steps.

  1. Log in

    You must be logged in to view this content. Log in now.

  2. Purchase Technical Presentation

    You must purchase this technical presentation using one of the options below.
    If you already purchased this content recently, please click here to refresh the system's record of ownerships.


Credits 0.5 Use credits
List Price $25.00 Buy now
AIChE Members $15.00 Buy now
AIChE Undergraduate Student Members Free Free access
AIChE Graduate Student Members $15.00 Buy now