2010

A systematic experimental study of the synthesis of copper oxide nanoparticles and nanoporous films is presented. Powders were made by flame spray pyrolysis method with end applications in the photoeclectrochemical production of hydrogen. Inhibited particle growth was observed for prticles made...

Photoelectrochemical (PEC) water splitting to produce clean hydrogen fuel is an attractive method for harvesting intermittent solar energy and storing it in the form of chemical bonds. A key photoelectrode material requirement is visible light absorption to maximize the number of photogenerated...

The use of electrospinning to generate one dimensional materials has garnered significant interest lately due to its inexpensive nature and the diversity of materials fabricated. Recently one dimensional materials have also been investigated to support catalytic nanoparticles to prevent aggregation...

Combined Quality-by-Design and computer simulation approaches (discrete element method and computational fluid dynamics) are presented to characterize key unit operations of solid dosage form manufacturing, namely powder blending and tablet coating. The aim is to evaluate the impact of formulation...

Present a case study on mixture DOE involving five components used to formulate a pharmaceutical tablet. The goal is to achieve a sustained release by optimizing the concentration of a hydrophilic polymer in relation to the proportions of a drug and three excipients. Four responses (two related to...

The presentation “Practical application of Q8 and Q9 principles in pharmaceutical development” gives an overview of the current practice in pharmaceutical development within the Oral Solid Dosage form Development department of Abbott in Weesp, the Netherlands. The presentation starts at the point...

Quality by Design is a technical exercise that should be performed upstream in the design of the production train for a given product. Although each processing step will have its own inputs and outputs that effect product quality, it is clear that raw materials properties are important for the...

The budget-restricted pharmaceutical environment is countered by the heightened expectations for drug products to be developed using science-based principles. These two opposing factors have created a crucial opportunity for engineering principles to be applied and implemented across the industry...

Drug dose response experiments in animals provide invaluable information about the pharmacokinetics and pharmacodynamics of new therapeutic agents. The drug response curves in various organs such as the liver, heart or brain hold quantitative information to ascertain the laws of drug fate in the...

Throughout its history, Genentech scientists and engineers pioneered and then exploited the use of recombinant DNA technology to develop and manufacture proteins and monoclonal antibodies for therapeutic use. Today an entire industry uses these genetic engineering techniques in pursuit of novel...