James T. Cobb Jr., Gary K. Patterson, S. Ranil Wickramasinghe
Diversification, globalization, emerging technologies...Times have certainly changed for chemical engineers. But, has the undergraduate chemical engineering curriculum kept pace?
Sterilization-in-place (SIP) systems are essential to the operation of many pharmaceutical and biotech facilities. This article reviews design considerations, selection criteria and performance expectations for control valves, regulators, isolation...
Christopher A. Bennett, David C. King, R. Stanley Kistler, Thomas G. Lestina
This article defines and explains the factors that affect heat exchanger design margins. With the proper application of design margins, capital costs can be lowered and plant operations improved.
Jonathan H. Worstell
The new parameter introduced here will yield more meaningful results when a fixed-bed reactor is scaled up for process development or scaled down for plant support.
John C. Birkmire, P.E.
Proper design, fabrication, assembly and operation of a pressure vessel closure are essential to ensuring product containment, integrity and quality.
Vladimir Kasyanov, Roger Markwald, Vladimir Mironov
Imagine eliminating patient waiting lists for organ transplants. Bioprinting holds the promise of making this happen, but, must research must be done first.
Baha Korkmaz, Marty Martin
By incorporating the batch standards S88 and S95 into the entire product lifecycle, companies can optimize their processes and project management. This enables them to rapidly get their products to market — a critical factor in staying competitive.
Modular design principles are well known, but have found only niche applications in the Chemical industry. This article outlines an innovative methodology, whereby plant and process design may be conducted in parallel using components with pre-...
Andrew J. DeDoes, Matthew D. Goetz, Michael J. Misovich
This method reproduces the vapor pressure predictions of the Soave-Redlich-Kwong and Peng-Robinson equation of state with a simple Antoine equation that uses constants derived from critical properties and the acentric factor.
Conceived more than seven decades ago, dividing-wall columns are now only gaining widespread acceptance. The reasons— the drive to save energy and advances in computer technology that have overcome the burden of doing complex column internal designs.
Scanning with an optical imaging camera is a faster, cheaper method of finding leaks in a maze of process equipment.
Geoffrey M. Spinks, Gordon G. Wallace
Inherently conducting polymers (ICPs) exhibit a variety of dynamic behaviors that make them an exciting platform for a new generation of bionic devices.
Gregory T. Benz
This commonly used number does not correctly address the influence of viscosity, and has no relationship to performance parameters such as fluid velocity and blend time. This article recommends actual measures of agitator performance that should be...
Daniel W. Allison, Christoph L. Bausch, Trissa Borgschulte, Matthew V. Caple, Kevin J. Kayser
Demand for therapeutic recombinant proteins will eventually exceed current production capabilities. This is a major driver in further understanding Chinese Hamster Ovary (CHO) cell biology, which is the cell line of choice for producing these...
Wes Bussman, Jianhui Hong, Charles E. Baukal Jr., Richard T. Waibel
High carbon monoxide emissions from a furnace while its temperature is being ramped up can exceed permit limits if appropriate measures are not taken. Here are a few suggestions.
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