(129b) A Systematic Study of Liquid and Solid Residence Time Distributions in a Dynamic Baffle Crystallizer
- Conference: World Congress on Particle Technology
- Year: 2018
- Proceeding: 8th World Congress on Particle Technology
- Group: Applications of Particle Technology for Pharmaceuticals
Thursday, April 26, 2018 - 8:38am-9:01am
In the work proposed here, the DBC is operated as a MSMPR vessel. A systematic study of residence time distribution (RTD), essential for studying the hydrodynamics of any new vessel, is carried out. A statistically sound design of experiment (DOE) is performed to investigate the effect of frequency, amplitude and flow rate. FTIR probe, capable of correcting for signal interference caused by oscillations, is used to monitor the solute concentration during tracer experiments. This study will improve the understanding of oscillatory systems as an alternative crystallization vessel and the understanding of the impact of different mixing mechanisms on the final crystal size distribution.
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