(124c) Crystal Polymorphism of Particles Formed Via Monodisperse Droplet Evaporation
In this talk, we will highlight our recent work on producing unexpected polymoprhs of crystalline particles via evaporation of monodisperse droplets using a vibrating orifice aerosol generator (VOAG). Varied particle morphologies will also be presented. Several organic molecular crystal systems will be presented including succinic acid, glycine, and suberic acid. As with other crystallization methods, the solvent is crucial in impacting both the resulting particle crystal polymorph(s) and the particle morphologies. For succinic acid we will demonstrate the formation of the alpha polymorph at room temperature and pressure using water as the solvent (Carver and Snyder, 2012), whereas it otherwise has previously only been isolated at elevated temperatures. For glycine, we will highlight the ability to form the beta polymorph from water solutions (Trauffer, Maassel and Snyder, 2016), whereas additional chemicals or modifiers typically are needed to form the beta polymorph. Last, we will present a preliminary potentially new polymorph of suberic acid. The use of a chemical additive to enhance or inhibit some of these polymorph formations also will be considered. Finally, we will consider the challenges and opportunities for using this technique both in other research applications as well as industrially.
Kelly M. Carver and Ryan C. Snyder; Industrial and Engineering Chemistry Research, 2012; 51: 15720-15728.
David I. Trauffer, Anna K. Maassel and Ryan C. Snyder; Crystal Growth and Design, 2016; 16: 1917â1922.