Scale-down to Scale-up More Efficiently

Authors: 
Schultz, M. A., PTI Solutions
The time and cost required to scale-up a new technology has been well documented. We can reduce the time and cost for scale-up by looking at the commercial design during the early stages of process development. This forms a basis to then 'scale-down', prioritizing the key variables and unit operations required to optimize the design and reduce technical risk throughout scale up. In addition, commercially proven unit operations can often be identified which can be adapted for the new process. Real world examples will be used to illustrate the advantages of this approach.

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