(680h) On the Feasibility of Utilising Compaction Equation Parameters As Material Key Attribute  Descriptors

10.0pt;line-height:115%;font-family:" arial>       In
pharmaceutical manufacturing processes such as pharmaceutical tableting, an
understanding of a materials flow behaviour is imperative, as it dictates
product quality in terms of content and weight uniformity [1].
Various compendial methods exist in measuring powder flow properties such as
bulk and tapped density, angle of repose, Carr’s compressibility index and
Hausner ratio [2].
Other methods such as dynamic flow and shear measurements can be undertaken
using a rheometer [2].
However, the accuracy of these methodologies is subject to performance
conditions, which may not be representative of the process in question [1].
Additionally, the knowledge of material specific key attributes such as a
materials susceptibility to lubricant poisoning also allows for the adequate
selection and pairing of materials during formulation development. The use of
compaction equations as a means of analysing the pharmaceutical compression
process of single- and multi-component powders and the physical correlation of
parameters to powder properties has the advantage of requiring significantly
less material and time. A combination of parameters from these equations has
been shown to provide a useful indication of critical material properties
during direct compression[3].
In recent work, it was observed that a combination of parameters from these
equations correlated well to derived compressibility values obtained from a
rheometer [3].
In the current work, selected parameters are compared to compendial
methodologies in order to establish the feasibility of utilising these
parameters as indicators for critical material attributes such as the flow
property and lubricant sensitivity of materials.

Figure 1: Correlation of compaction parameter ab
to measured compressibility values

References

1.               Prescott,
J.K. and R.A. Barnum, On powder flowability. Pharmaceutical technology,
2000. 24(10): p. 60-85.

2.               Shah,
R.B., M.A. Tawakkul, and M.A. Khan, Comparative evaluation of flow for
pharmaceutical powders and granules. AAPS PharmSciTech, 2008. 9(1):
p. 250-258.

3.               Solomon,
S., et al., Particle Engineering of Excipients: A Mechanistic Investigation
into the Compaction Properties of Lignin and [Co]-Spray Dried Lignin.
International Journal of Pharmaceutics, 2019.