(342g) Understanding of a Continuous Barbier-Type Grignard Process Via Mechanistic Modeling
- Conference: AIChE Annual Meeting
- Year: 2019
- Proceeding: 2019 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Tuesday, November 12, 2019 - 2:35pm-3:00pm
Due to their heterogeneous nature and the hazards associated with processing highly exothermic mixtures, Grignard reactions can be challenging to operate at production scale. This presentation focuses on the development of a mechanistic model for this challenging class of reactions and the utilization of the developed model to investigate and identify operating conditions that satisfy process constraints for continuous manufacturing. Batch experiments were designed and executed to provide the kinetics data for estimating the kinetic parameters. The model was also compared with existing fit-for-purpose models in the literature.