(334j) Dynamics of Elastic Multi-Compartment Capsules in Microfluidic Channels

Over the last decade, there has been an increasing interest in producing
and studying more complex soft particles such as multi-compound particles,
droplets and capsules. The multi-compartment elastic capsules show great
potential in smart drug delivery and on-demand release. The study of
these capsules is further motivated by common physiological complex
capsules, including leukocytes, malaria infected erythrocytes, and
generally cells with inner nuclei.

In the present talk, our interest is concentrated on the hydrodynamics
of multi-compartment elastic capsules in microfluidic channels. In our
computation investigation, we study a wide range of inner-capsule sizes
and types as well as flow rates. The effects of the presence of inner
capsules on the deformation and motion of the mother capsule in confined
microfluidic flows will also be presented. We will also discuss the
tensions development on all membranes which is associated with possible
membrane rupture. Our work provides useful physical insight on the
smart drug delivery, and the filtration and sorting of complex capsules
and cells.