(723b) Polymorph Screening of L-Glutamic Acid By Anti-Solvent Crystallization in Easy-to-Use Microfluidic Device
AIChE Annual Meeting
Thursday, November 1, 2018 - 3:55pm to 4:15pm
In this work, based on anti-solvent crystallization, solutions and antisolvent were loaded into separate syringes which were connected to channels. By varying the initial concentrations of solutions, temperature, and velocities of solution and antisolvent, the resulted crystals were flitered directly, and dried in an air oven. Then crystals were characterized by SEM and PXRD for morphology evaluation and form confirmation. The polymorph selectivity of L-glutamic acid was investigated. This method was simple in operation and low consumption was required. And the crystallization temperature was kept constant throughout the process. The results showed that this method was more flexible in the selectivity of L-glutamic acid polymorphs without other assistive technologies or additives which might introduce impurities.