(610e) Polymorph Dynamics of 2-Aminobenzoic Acid System in Continuous Oscillatory Baffled Crystallizer

The polymorph dynamics
of 2-Aminobenzoic acid is investigated in a continuous oscillatory baffled
crystallizer (COBC). The COBC is a tubular crystallizer containing periodically
spaced orifice baffles with oscillatory motion superimposed on the net flow.^[1]
A Nitech DN15 COBC consisting of eight segments with each segment and
elbow jacketed for temperature control is used for the studies. Preliminary
experiments show the feasibility of generating the two polymorphs in the COBC
via continuous cooling crystallization. However, in order to obtain higher
yield combined cooling and antisolvent crystallization (CCAC) is used. In
pharmaceutical industry traditionally an antisolvent is added to the solution
to increase the yield of the product. However, the presence of the antisolvent
can influence the polymorphic outcome.^[2] Design of experiments are
done to investigate the effects of the parameters – temperature, solvent
composition and residence time. The poster will show additional detail studies
such as the effect of mixing parameters – piston amplitude and frequency of
oscillation on the polymorphic outcome and yield.

^[1]Caldeira, R., Ni, X.
2009 Evaluation and Establishment of a Cleaning Protocol for the Production of
Vanisal Sodium and Aspirin using a Continuous Oscillatory Baffled Reactor. Org.
Process Res. Dev. 13(6), 1080–1087.

^[2]Lindenberg, C., Krättli,
M., Cornel, J., Mazzotti, M., & Brozio, J. 2008. Design and Optimization of
a Combined Cooling/Antisolvent Crystallization Process. Cryst. Growth Des. 9(2),
1124–1136.