(424b) Process Modeling, Simulation and Optimization of Process Intensification in Integrated Biorefineries
Butanol can be produced by fermentation of sugars derived from lignocellulosic biomass. However, there are key challenges in butanol biorefineries: (i) severe product (i.e butanol) inhibition due to toxicity to the microorganisms during fermentation, which leads to low butanol yield and productivity, and (ii) expensive downstream processing (product separation and purification). This paper is focused on the process intensification and integration of bioprocessing and separation technologies, i.e., integration of efficient separation process with fermentation for in situ removal of product inhibitor to increase the butanol yield and productivity and lower the production cost. The comparison of energy consumption between different separation approaches is carried out by modeling and analysis of the integrated biorefinery, based on recent research, with process intensification and integration of bioprocessing and separation of products (e.g., Fig 1). Process optimization will also be carried out.