(301c) Prediction of Loss-in-Weight Screw Feeder Performance and Quantification of Failure Modes from Attribute Measurements of Pharmaceutical Materials
AIChE Annual Meeting
Tuesday, October 30, 2018 - 8:36am to 8:54am
To this end, we have conducted empirical studies to assess feeder throughput accuracy for commercially available loss-in-weight feeder configurations. A variety of components spanning a range of cohesivities, compressabilities and yield stresses have been assessed. Feed failure modes indicative of process robustness have been categorized and statistically quantified to develop predictive relationships with lab measurements of materials properties performed with gram-scale quantities. These include particle size distribution, bulk and tapped density; permeability, morphology and flowability (as assessed by both direct arching tests and by shear cell measurements of flow function and angle of internal friction). Along with equipment geometric descriptors, performance envelopes are defined. Results are evaluated against theoretical considerations and guidance around practical strategies for predictive assessment of feeder performance is outlined.