(270d) Model Based Process Design on Continuous Cooling Crystallization
In addition, we will perform a design of experiment (DOE) to systematically determine the design space to produce products of a certain size and polymorphic composition range. The population balance model (PBM) will be used to simulate our continuous crystallization processes. Five factors considered in the determination of the design space are: feed concentration, initial concentration, seed loading, seed crystal size distribution, and residence time. Various points within the design space and at the boundaries were evaluated experimentally.
- Lee, S. L.; OâConnor, T. F.; Yang, X.; Cruz, C. N.; Chatterjee, S.; Madurawe, R. D.; Moore, C. M.; Lawrence, X. Y.; Woodcock, J., Modernizing pharmaceutical manufacturing: from batch to continuous production. J Pharm Innov 2015, 10 (3), 191-199.
- Yang, X.; Acevedo, D.; Mohammad, A.; Pavurala, N.; Wu, H.; Brayton, A. L.; Shaw, R. A.; Goldman, M. J.; He, F.; Li, S.; Fisher, R. J.; OâConnor, T. F.; Cruz, C. N., Risk Considerations on Developing a Continuous Crystallization System for Carbamazepine. Organic Process Research & Development 2017.