(623c) Nonlinear First-Principle Model-Based Control of a Continuous Pharmaceutical Manufacturing Process
- Conference: AIChE Annual Meeting
- Year: 2017
- Proceeding: 2017 Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Wednesday, November 1, 2017 - 3:57pm-4:18pm
In this work, a nonlinear first-principle distributed dynamic model was developed to control a drying process for continuous manufacturing of orally dissolving films loaded with a pharmaceutical compound. The drying model is the core of active control for the process, in which the process parameters (such as air temperature, or production rate), feed compositions (like solid content and concentration), or final productsâ properties (for instance the required final moisture content) can be the manipulating variables. Simulation of transport phenomena, diffusion controlled mass transfer (mutual solvent-polymer vs. moisture sorption isotherm), the spatial distribution of solvent concentration in the film and the moving boundary on the interface due to the thin film shrinkage during drying are some of the complexities of the model development. The final quality attribute of the product is set as the control set point and other process variables were manipulated in the nonlinear model control (MIMO) to converge the process in the design space of variable inputs. The model funds the steps for future phases of PAT implementation, RTRt, and process optimization.