(539e) A Comparative Study of Continuous Crystallization in an Oscillatory Baffled Crystallizer and a Mixed-Suspension-Mixed-Product-Removal Crystallizer
- Conference: AIChE Annual Meeting
- Year: 2017
- Proceeding: 2017 Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Wednesday, November 1, 2017 - 1:58pm-2:20pm
In the work proposed here, a comparison between continuous crystallization in an MSMPR versus an OBR is carried out to assess the differences in final product properties. Continuous operation in both vessels is achieved using peristaltic pumps and vacuum for slurry removal. The residence time distribution (RTD) is studied in each system using homogeneous and heterogenous tracers at different mixing conditions. Continuous cooling crystallizations of paracetamol is then evaluated in both crystallizers at the same feed concentration and mean residence time with varying power density levels. At each power density level, the start-up time and steady state crystal properties (i.e. mean size, CSD) are analyzed to determine the effect of hydrodynamics. A rigid and robust online FTIR probe, capable of correcting for signal interference caused by oscillations, is used to monitor the solute concentration during operation. This study will improve the understanding of oscillatory systems as an alternative crystallization vessel and the understanding of the impact of different mixing mechanisms on the final crystal size distribution.
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