(539d) Continuous Heterogeneous Crystallization and the New Method of Making Tablets
- Conference: AIChE Annual Meeting
- Year: 2017
- Proceeding: 2017 Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Wednesday, November 1, 2017 - 1:36pm-1:58pm
Within the range of our analysis, proportional drug loading can be easily tailored for a wide range depending on required drug dosage per tablet. The fully continuous processes, and eliminating the downstream steps result in producing crystalline compounds and final form (tablets) in significantly faster, more efficient, with lower footprint, and more economical. This novel approach eliminates almost all the conventional unit operations in the drug product process, by connecting the API purification and crystallization step directly to the tablet making final stage.
KEYWORDS: Continuous manufacturing, Heterogeneous nucleation, Surface facilitated nucleation, Drug product