(341b) Process Synthesis for Improved Bioseparations Using Multi-Resin Simulated Moving Bed Chromatography
In this work, we optimize the profitability of the SMB chromatography by considering the process design and the resin material selection by improving upon an MINLP model developed by Hasan and Floudas.2 We apply this improved model to the case study of the industrially-relevant fructose-glucose separation and beta-carotene extracted from Saccharomyces cerevisiae to improve the productivity and profitability. Separation parameters are determined experimentally for each resin and used in the modified MINLP model. The multi-resin SMB chromatography will be compared to the single-resin to SMB chromatography process to show the increase profitability.
- S. V. Vignesh, K. Hariprasad, P. Athawale, and S. Bhartiya, âAn optimization-driven novel operation of simulated moving bed chromatographic separation,â IFAC-PapersOnLine, vol. 49, no. 7, pp. 165â170, Jan. 2016.
- M. M. Faruque Hasan, E. L. First, and C. A. Floudas, âDiscovery of novel zeolites and multi-zeolite processes for p-xylene separation using simulated moving bed (SMB) chromatography,â Chemical Engineering Science, vol. 159, pp. 3â17, Feb. 2017.