(299c) Modeling and Monitoring of a Continuous Silylation Reaction
- Conference: AIChE Annual Meeting
- Year: 2017
- Proceeding: 2017 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Tuesday, October 31, 2017 - 8:50am-9:15am
A multi-step kinetic mechanism was proposed based upon the experimentation and orthogonal simulation results. The impact of reaction temperature, solvent concentration, and recipe were investigated. The model has been applied to both batch and continuous processes. Discussion will include sharing key learning from the model development and its application toward risk management and understanding the feasible operating region.