(742f) 3D Raman Spectroscopy – a Method for Mapping Ingredient Distribution throughout a Tablet Volume
AIChE Annual Meeting
Thursday, November 17, 2016 - 5:05pm to 5:27pm
Raman imaging is a powerful tool for studying tablet structure. It has higher chemical specificity than NIR and is also less affected by physical characteristics of the sample. The main disadvantage of Raman, its low quantum yield, requiring long integration times, is vanishing quickly, due to vast advances made recently in laser and detector technology. This is causing a significant renewed interest in using chemical mapping to examine the microstructure of pharmaceutical tablets.
This talk will focus on the use of a new Raman imaging platform, the mPAT system from H2Optx, which is equipped with a 10x10 micron 2D spatial resolution along with the ability to shave layers off a tablet for depth analysis. This level of spatial resolution enables the user to extract detailed structural data that reveals the relationships between process, product structure, and product performance. This technique has the ability to do a quantitative content determination within a sample and, combining this for each pixel, generate 3D maps w.r.t. the individual constituents.
Tablets manufactured from traditional batch processing methods and continuous manufacturing methods were examined, including tablets made via Direct Compaction (DC), Wet Granulation (WG) and Roller Compaction (RC). Tablets using several formulations for each of the three methods were made with various levels of induced agglomeration and were analyzed using the mPAT system. The effects of the different processing conditions on agglomeration were characterized and their effect on tablet microstructure and dissolution were quantified. These observations will be discussed in this presentation.