(286e) Process Intensification for Continuous Slug-Flow Crystallization
AIChE Annual Meeting
Tuesday, November 15, 2016 - 9:55am to 10:15am
This presentation will elaborate: (1) the process design and strategies for continuous slug-flow crystallization that controls the crystallization phenomena; (2) nucleation systems based on multiphase hydrodynamics from joining two streams in dual impinging jet, coaxial, or radial micromixers, which has been demonstrated to produce seed crystals of uniform crystal size distribution (CSD) , with a nucleation rate that depends on the liquid flow rate ; and (3) nucleation facilitated by advanced ultrasonication (e.g., focused and indirect) which provides extra degrees of freedom for controlling the CSD by decoupling the nucleation rate from liquid flow rate . Process intensification strategy to improve the crystal growth control is also discussed which makes the whole process more robust. Experimental validation confirms that the proposed crystallizer designs reduce production time and equipment cost by orders of magnitude while suppressing secondary nucleation, attrition, and aggregationâ??dominant but undesired phenomena that worsen the ability to control the crystal properties.
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