(284a) Mass Transfer Characterization of a Biphasic Continuous Reaction System for Improved Process Understanding and Control
- Conference: AIChE Annual Meeting
- Year: 2016
- Proceeding: 2016 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Tuesday, November 15, 2016 - 8:30am-8:52am
A key asset in the continuous portfolio at GlaxoSmithKline involves process development of a partially miscible chemical reaction mixture, in which the reaction is limited by mass transfer. To support process understanding, control, and scale-up from the laboratory to pilot plant facilities, a protocol was developed to characterize the mass transfer of the system in terms of fundamental engineering first principles. This presentation will detail the characterization of a partially miscible mass transfer limited reaction for continuous processing including observations of equipment specific scale-up parameters.